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Gap junctions in the ovary: Expression, localization and function
Year:
2008
Authors :
Gershon, Eran
;
.
Volume :
282
Co-Authors:
Gershon, E., Department of Biological Regulation, Weizmann Institute of Science, Rehovot, 76100, Israel
Plaks, V., Department of Biological Regulation, Weizmann Institute of Science, Rehovot, 76100, Israel
Dekel, N., Department of Biological Regulation, Weizmann Institute of Science, Rehovot, 76100, Israel
Facilitators :
From page:
18
To page:
25
(
Total pages:
8
)
Abstract:
Gap junctions that allow the direct communication between cytoplasmic compartments of neighboring cells are present in a variety of tissues and organs and play pivotal roles in a wide range of physiological processes. In the ovary, gap junctions consist mainly of connexin (Cx) 43 and Cx37, and their indispensable role in regulating folliculogenesis and oogenesis is well established. The ovarian Cx43 is regulated by gonadotropins at the transcriptional, translational and post-translational levels whereas the regulation of the ovarian Cx37 is yet unknown. In addition to their involvement in normal ovarian functions, gap junction proteins, particularly Cx43, seem to act as cancer suppressors. A summary of our present knowledge regarding gap junctional communication (GJC) and the ovarian gap junction proteins in normally developing ovaries and under pathological conditions is presented in this review. © 2007 Elsevier Ireland Ltd. All rights reserved.
Note:
Related Files :
Animals
cattle
connexin 37
Female
Gap junction
mice
oocyte maturation
protein function
protein localization
sheep
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More details
DOI :
10.1016/j.mce.2007.11.001
Article number:
Affiliations:
Database:
Scopus
Publication Type:
article
;
.
Language:
English
Editors' remarks:
ID:
31273
Last updated date:
02/03/2022 17:27
Creation date:
17/04/2018 01:01
Scientific Publication
Gap junctions in the ovary: Expression, localization and function
282
Gershon, E., Department of Biological Regulation, Weizmann Institute of Science, Rehovot, 76100, Israel
Plaks, V., Department of Biological Regulation, Weizmann Institute of Science, Rehovot, 76100, Israel
Dekel, N., Department of Biological Regulation, Weizmann Institute of Science, Rehovot, 76100, Israel
Gap junctions in the ovary: Expression, localization and function
Gap junctions that allow the direct communication between cytoplasmic compartments of neighboring cells are present in a variety of tissues and organs and play pivotal roles in a wide range of physiological processes. In the ovary, gap junctions consist mainly of connexin (Cx) 43 and Cx37, and their indispensable role in regulating folliculogenesis and oogenesis is well established. The ovarian Cx43 is regulated by gonadotropins at the transcriptional, translational and post-translational levels whereas the regulation of the ovarian Cx37 is yet unknown. In addition to their involvement in normal ovarian functions, gap junction proteins, particularly Cx43, seem to act as cancer suppressors. A summary of our present knowledge regarding gap junctional communication (GJC) and the ovarian gap junction proteins in normally developing ovaries and under pathological conditions is presented in this review. © 2007 Elsevier Ireland Ltd. All rights reserved.
Scientific Publication
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