אסיף מאגר המחקר החקלאי

Gap junctions in the ovary: Expression, localization and function

Year:

2008

Source of publication :

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Volume :

282

Co-Authors:

Gershon, E., Department of Biological Regulation, Weizmann Institute of Science, Rehovot, 76100, Israel
Plaks, V., Department of Biological Regulation, Weizmann Institute of Science, Rehovot, 76100, Israel
Dekel, N., Department of Biological Regulation, Weizmann Institute of Science, Rehovot, 76100, Israel

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Abstract:

Gap junctions that allow the direct communication between cytoplasmic compartments of neighboring cells are present in a variety of tissues and organs and play pivotal roles in a wide range of physiological processes. In the ovary, gap junctions consist mainly of connexin (Cx) 43 and Cx37, and their indispensable role in regulating folliculogenesis and oogenesis is well established. The ovarian Cx43 is regulated by gonadotropins at the transcriptional, translational and post-translational levels whereas the regulation of the ovarian Cx37 is yet unknown. In addition to their involvement in normal ovarian functions, gap junction proteins, particularly Cx43, seem to act as cancer suppressors. A summary of our present knowledge regarding gap junctional communication (GJC) and the ovarian gap junction proteins in normally developing ovaries and under pathological conditions is presented in this review. © 2007 Elsevier Ireland Ltd. All rights reserved.

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