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Amh and Dmrta2 genes map to tilapia (Oreochromis spp.) linkage group 23 within quantitative trait locus regions for sex determination
Year:
2006
Source of publication :
Genetics (source)
Authors :
Cnaani, Avner
;
.
Domokhovsky, Raisa
;
.
Hulata, Gideon
;
.
Ron, Micha
;
.
Seroussi, Eyal
;
.
Shirak, Andrey
;
.
Zilberman, Noam
;
.
Volume :
174
Co-Authors:
Shirak, A., Institute of Animal Science, Agricultural Research Organization, Volcani Center, Bet Dagan 50250, Israel
Seroussi, E., Institute of Animal Science, Agricultural Research Organization, Volcani Center, Bet Dagan 50250, Israel
Cnaani, A., Hubbard Center for Genome Studies, University of New Hampshire, Durham, NH 03824, United States
Howe, A.E., Hubbard Center for Genome Studies, University of New Hampshire, Durham, NH 03824, United States
Domokhovsky, R., Institute of Animal Science, Agricultural Research Organization, Volcani Center, Bet Dagan 50250, Israel
Zilberman, N., Institute of Animal Science, Agricultural Research Organization, Volcani Center, Bet Dagan 50250, Israel
Kocher, T.D., Hubbard Center for Genome Studies, University of New Hampshire, Durham, NH 03824, United States
Hulata, G., Institute of Animal Science, Agricultural Research Organization, Volcani Center, Bet Dagan 50250, Israel, Institute of Animal Science, Agricultural Research Organization, Volcani Center, P. O. Box 6, Bet Dagan 50250, Israel
Ron, M., Institute of Animal Science, Agricultural Research Organization, Volcani Center, Bet Dagan 50250, Israel
Facilitators :
From page:
1573
To page:
1581
(
Total pages:
9
)
Abstract:
Recent studies have revealed that the major genes of the mammalian sex determination pathway are also involved in sex determination of fish. Several studies have reported QTL in various species and strains of tilapia, regions contributing to sex determination have been identified on linkage groups 1, 3, and 23. Genes contributing to sex-specific mortality have been detected on linkage groups 2, 6, and 23. To test whether the same genes might control sex determination in mammals and fishes, we mapped 11 genes that are considered putative master key regulators of sex determination: Amh, Cyp19, Dax1, Dmrt2, Dmrta2, Fhl3l, Foxl2, Ixl, Lhx9, Sf1, and Sox8. We identified polymorphisms in noncoding regions of these genes and genotyped these sites for 90 individuals of an F2 mapping family. Mapping of Dax1 joined LG16 and LG21 into a single linkage group. The Amh and Dmrta2 genes were mapped to two distinct regions of LG23. The Amh gene was mapped 5 cM from UNH879 within a QTL region for sex determination and 2 cM from UNH216 within a QTL region for sex-specific mortality. Dmrta2 was mapped 4 cM from UNH848 within another QTL region for sex determination. Cyp19 was mapped to LG1 far from a previously reported QTL region for sex determination on this chromosome. Seven other candidate genes mapped to LG4, -11, -12, -14, and -17. Copyright © 2006 by the Genetics Society of America.
Note:
Related Files :
Animals
chromosome mapping
Female
Gene
genetic markers
Male
Tilapia
Show More
Related Content
More details
DOI :
10.1534/genetics.106.059030
Article number:
Affiliations:
Database:
Scopus
Publication Type:
article
;
.
Language:
English
Editors' remarks:
ID:
31277
Last updated date:
02/03/2022 17:27
Creation date:
17/04/2018 01:01
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Scientific Publication
Amh and Dmrta2 genes map to tilapia (Oreochromis spp.) linkage group 23 within quantitative trait locus regions for sex determination
174
Shirak, A., Institute of Animal Science, Agricultural Research Organization, Volcani Center, Bet Dagan 50250, Israel
Seroussi, E., Institute of Animal Science, Agricultural Research Organization, Volcani Center, Bet Dagan 50250, Israel
Cnaani, A., Hubbard Center for Genome Studies, University of New Hampshire, Durham, NH 03824, United States
Howe, A.E., Hubbard Center for Genome Studies, University of New Hampshire, Durham, NH 03824, United States
Domokhovsky, R., Institute of Animal Science, Agricultural Research Organization, Volcani Center, Bet Dagan 50250, Israel
Zilberman, N., Institute of Animal Science, Agricultural Research Organization, Volcani Center, Bet Dagan 50250, Israel
Kocher, T.D., Hubbard Center for Genome Studies, University of New Hampshire, Durham, NH 03824, United States
Hulata, G., Institute of Animal Science, Agricultural Research Organization, Volcani Center, Bet Dagan 50250, Israel, Institute of Animal Science, Agricultural Research Organization, Volcani Center, P. O. Box 6, Bet Dagan 50250, Israel
Ron, M., Institute of Animal Science, Agricultural Research Organization, Volcani Center, Bet Dagan 50250, Israel
Amh and Dmrta2 genes map to tilapia (Oreochromis spp.) linkage group 23 within quantitative trait locus regions for sex determination
Recent studies have revealed that the major genes of the mammalian sex determination pathway are also involved in sex determination of fish. Several studies have reported QTL in various species and strains of tilapia, regions contributing to sex determination have been identified on linkage groups 1, 3, and 23. Genes contributing to sex-specific mortality have been detected on linkage groups 2, 6, and 23. To test whether the same genes might control sex determination in mammals and fishes, we mapped 11 genes that are considered putative master key regulators of sex determination: Amh, Cyp19, Dax1, Dmrt2, Dmrta2, Fhl3l, Foxl2, Ixl, Lhx9, Sf1, and Sox8. We identified polymorphisms in noncoding regions of these genes and genotyped these sites for 90 individuals of an F2 mapping family. Mapping of Dax1 joined LG16 and LG21 into a single linkage group. The Amh and Dmrta2 genes were mapped to two distinct regions of LG23. The Amh gene was mapped 5 cM from UNH879 within a QTL region for sex determination and 2 cM from UNH216 within a QTL region for sex-specific mortality. Dmrta2 was mapped 4 cM from UNH848 within another QTL region for sex determination. Cyp19 was mapped to LG1 far from a previously reported QTL region for sex determination on this chromosome. Seven other candidate genes mapped to LG4, -11, -12, -14, and -17. Copyright © 2006 by the Genetics Society of America.
Scientific Publication
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