אסיף מאגר המחקר החקלאי

Short communication: A polymorphism in ABCG2 in Bos indicus and Bos taurus cattle breeds

Year:

2006

Source of publication :

Authors :

Volume :

89

Co-Authors:

Ron, M., Department of Ruminants and Genetics, Agricultural Research Organization, P.O.B. 6, Bet-Dagan 50-250, Israel
Cohen-Zinder, M., Department of Ruminants and Genetics, Agricultural Research Organization, P.O.B. 6, Bet-Dagan 50-250, Israel
Peter, C., Department of Animal Breeding and Genetics, Justus-Liebig-University Giessen, Ludwigstrasse 21b, 35390 Giessen, Germany
Weller, J.I., Department of Ruminants and Genetics, Agricultural Research Organization, P.O.B. 6, Bet-Dagan 50-250, Israel
Erhardt, G., Department of Animal Breeding and Genetics, Justus-Liebig-University Giessen, Ludwigstrasse 21b, 35390 Giessen, Germany

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Abstract:

A single nucleotide change (A/C) in exon 14 is capable of encoding a substitution of tyrosine-581 to serine (Y581S) in the ABCG2 (ATP binding cassette, subfamily G, member 2) gene and affects milk production traits. The ABCG2A allele decreases milk yield and increases protein and fat concentration. The allele frequencies were determined in 32 Bos taurus and 3 Bos indicus breeds; ABCG2A was predominant in all populations. This allele approached fixation in 23 out of 35 breeds, including all 3 Bos indicus breeds. The ABCG2C allele was found in the Belgian Blue (beef), Belgian Blue Mix, British Friesian, Bohemian Red, East Anatolian Red, German Angus, German Black Pied, German Brown, German Simmental, Israeli Holstein, Menorquina, and US Holstein breeds. Thus, the genetic gain expected from selection for ABCG2A may be limited. The detection of ABCG2 C only in Bos taurus breeds may indicate that ABCG2A is the ancestral allele, and that the Y581S substitution occurred after the separation of the Bos indicus and Bos taurus lineages. © American Dairy Science Association, 2006.

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