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The effect of active immunization against progesterone on plasma concentrations of total and free progesterone, estradiol-17β and LH in the cyclic ewe
Year:
1987
Source of publication :
Theriogenology
Authors :
Amir, David
;
.
Folman, Yeshayahu
;
.
Volume :
28
Co-Authors:
Rosenberg, M., Institute of Animal Science, A.R.O., The Volcani center, Bet Dagan, 50250, Israel
Amir, D., Institute of Animal Science, A.R.O., The Volcani center, Bet Dagan, 50250, Israel
Folman, Y., Institute of Animal Science, A.R.O., The Volcani center, Bet Dagan, 50250, Israel
Facilitators :
From page:
417
To page:
426
(
Total pages:
10
)
Abstract:
Nine mature cyclic ewes were actively immunized against progesterone which was rendered immunogenic by conjugation to bovine serum albumin (BSA). Seven control ewes were immunized with BSA. In ewes immunized against progesterone, the concentration of total plasma progesterone increased to 24.3 ng/ml vs 2.8 ng/ml in control animals (P<0.001). However, immunization did not affect the plasma levels of free, unbound progesterone. The correlation coefficient between total plasma progesterone concentrations on Days 4 to 11 of the estrous cycle and antibody titer was r=0.983. Estradiol-17β concentrations in immunized ewes were higher than in controls on Days 6 to 15 of the estrous cycle (P∼0.05). Frequent sampling for LH over a 6-h period on Days 2, 5, 8, 11 and 14 of the cycle revealed no significant differences in the frequency and amplitude of LH pulses between immunized and control ewes. The immunized ewes had estrous cycles of normal length and maintained normal pregnancies. It is suggested that the immunized cyclic ewe is capable of maintaining adequate levels of free progesterone by greatly increasing progesterone synthesis, thus neutralizing the effect of the antibodies. © 1987.
Note:
Related Files :
ewe
Immunization
progesterone
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More details
DOI :
10.1016/0093-691X(87)90246-9
Article number:
Affiliations:
Database:
Scopus
Publication Type:
article
;
.
Language:
English
Editors' remarks:
ID:
31297
Last updated date:
02/03/2022 17:27
Creation date:
17/04/2018 01:01
Scientific Publication
The effect of active immunization against progesterone on plasma concentrations of total and free progesterone, estradiol-17β and LH in the cyclic ewe
28
Rosenberg, M., Institute of Animal Science, A.R.O., The Volcani center, Bet Dagan, 50250, Israel
Amir, D., Institute of Animal Science, A.R.O., The Volcani center, Bet Dagan, 50250, Israel
Folman, Y., Institute of Animal Science, A.R.O., The Volcani center, Bet Dagan, 50250, Israel
The effect of active immunization against progesterone on plasma concentrations of total and free progesterone, estradiol-17β and LH in the cyclic ewe
Nine mature cyclic ewes were actively immunized against progesterone which was rendered immunogenic by conjugation to bovine serum albumin (BSA). Seven control ewes were immunized with BSA. In ewes immunized against progesterone, the concentration of total plasma progesterone increased to 24.3 ng/ml vs 2.8 ng/ml in control animals (P<0.001). However, immunization did not affect the plasma levels of free, unbound progesterone. The correlation coefficient between total plasma progesterone concentrations on Days 4 to 11 of the estrous cycle and antibody titer was r=0.983. Estradiol-17β concentrations in immunized ewes were higher than in controls on Days 6 to 15 of the estrous cycle (P∼0.05). Frequent sampling for LH over a 6-h period on Days 2, 5, 8, 11 and 14 of the cycle revealed no significant differences in the frequency and amplitude of LH pulses between immunized and control ewes. The immunized ewes had estrous cycles of normal length and maintained normal pregnancies. It is suggested that the immunized cyclic ewe is capable of maintaining adequate levels of free progesterone by greatly increasing progesterone synthesis, thus neutralizing the effect of the antibodies. © 1987.
Scientific Publication
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