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Raocyclamides A and B, novel cyclic hexapeptides isolated from the cyanobacterium Oscillatoria raoi
Year:
1996
Source of publication :
Journal of Natural Products
Authors :
Afek, Uzi
;
.
Volume :
59
Co-Authors:
Admi, V., School of Chemistry, Raymond Beverly Sackler Fac. E., Tel Aviv University, Ramat Aviv, Tel Aviv 69978, Israel
Afek, U., Dept. of Postharvest and Fresh Prod., Volcani Center, Bet Dagan 50250, Israel
Carmeli, S., School of Chemistry, Raymond Beverly Sackler Fac. E., Tel Aviv University, Ramat Aviv, Tel Aviv 69978, Israel
Facilitators :
From page:
396
To page:
399
(
Total pages:
4
)
Abstract:
Raocyclamides A and B, two novel oxazole- and thiazole-containing cyclic hexapeptides, were isolated from the cyanobacterium Oscillatoria raoi (TAU strain IL-76-1-2). The gross structures of raocyclamides A (1) and B (2) were elucidated by homonuclear and inverse-heteronuclear 2D-NMR techniques and HREIMS. The absolute stereochemistry of compounds 1 and 2 was determined by Marfey's HPLC Method. Raocyclamide A (1) was established as cyclo-thiazole- D-Ile-oxazole-L-Ala-D-oxazoline-D-Phe and raocyclamide B (2) as cyclo- thiazole-D-Ile-oxazole-L-Ala-D-Ser-D-Phe. Raocyclamide A (1) exhibits a moderate cytotoxicity against sea urchin embryos.
Note:
Related Files :
animal tissue
article
cyclopeptide
embryo
hexapeptide
nuclear magnetic resonance
protein isolation
sea urchin
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More details
DOI :
10.1021/np960115+
Article number:
Affiliations:
Database:
Scopus
Publication Type:
article
;
.
Language:
English
Editors' remarks:
ID:
31496
Last updated date:
02/03/2022 17:27
Creation date:
17/04/2018 01:03
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Scientific Publication
Raocyclamides A and B, novel cyclic hexapeptides isolated from the cyanobacterium Oscillatoria raoi
59
Admi, V., School of Chemistry, Raymond Beverly Sackler Fac. E., Tel Aviv University, Ramat Aviv, Tel Aviv 69978, Israel
Afek, U., Dept. of Postharvest and Fresh Prod., Volcani Center, Bet Dagan 50250, Israel
Carmeli, S., School of Chemistry, Raymond Beverly Sackler Fac. E., Tel Aviv University, Ramat Aviv, Tel Aviv 69978, Israel
Raocyclamides A and B, novel cyclic hexapeptides isolated from the cyanobacterium Oscillatoria raoi
Raocyclamides A and B, two novel oxazole- and thiazole-containing cyclic hexapeptides, were isolated from the cyanobacterium Oscillatoria raoi (TAU strain IL-76-1-2). The gross structures of raocyclamides A (1) and B (2) were elucidated by homonuclear and inverse-heteronuclear 2D-NMR techniques and HREIMS. The absolute stereochemistry of compounds 1 and 2 was determined by Marfey's HPLC Method. Raocyclamide A (1) was established as cyclo-thiazole- D-Ile-oxazole-L-Ala-D-oxazoline-D-Phe and raocyclamide B (2) as cyclo- thiazole-D-Ile-oxazole-L-Ala-D-Ser-D-Phe. Raocyclamide A (1) exhibits a moderate cytotoxicity against sea urchin embryos.
Scientific Publication
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