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Control of calcium absorption and intestinal calcium-binding protein synthesis
Year:
1973
Authors :
Bär, Arie
;
.
Volume :
54
Co-Authors:
Bar, A., Department of Physical Biology, New York State Veterinary College, Cornell University Ithaca, NY 14850, United States
Wasserman, R.H., Department of Physical Biology, New York State Veterinary College, Cornell University Ithaca, NY 14850, United States
Facilitators :
From page:
191
To page:
196
(
Total pages:
6
)
Abstract:
A current hypothesis suggests that the degree of Ca absorption is hormonally controlled via the feed-back regulation of 1,25-dihydroxycholecalciferol (1,25-(OH)2D3) production from 25-hydroxycholecalciferol (25-OHD3) by kidney 1-hydroxylase. To test this hypothesis, dihydrotachysterol3 (DHT3), a steroid not requiring 1-hydroxylation for biological activity, was given to chicks as the only source of vitamin D-activity. As expected, DHT3-treated chicks did not adapt to a calcium-deficient diet. However, both the efficiency of Ca absorption and net synthesis of CaBP were stimulated in DHT3-treated chicks by a low phosphorus intake, providing evidence for an alternate pathway of control. © 1973.
Note:
Related Files :
Adaptation, Physiological
Animal
calcitriol
Chickens
Duodenum
Intestinal Mucosa
Male
proteins
Show More
Related Content
More details
DOI :
10.1016/0006-291X(73)90907-8
Article number:
Affiliations:
Database:
Scopus
Publication Type:
article
;
.
Language:
English
Editors' remarks:
ID:
32310
Last updated date:
02/03/2022 17:27
Creation date:
17/04/2018 01:08
Scientific Publication
Control of calcium absorption and intestinal calcium-binding protein synthesis
54
Bar, A., Department of Physical Biology, New York State Veterinary College, Cornell University Ithaca, NY 14850, United States
Wasserman, R.H., Department of Physical Biology, New York State Veterinary College, Cornell University Ithaca, NY 14850, United States
Control of calcium absorption and intestinal calcium-binding protein synthesis
A current hypothesis suggests that the degree of Ca absorption is hormonally controlled via the feed-back regulation of 1,25-dihydroxycholecalciferol (1,25-(OH)2D3) production from 25-hydroxycholecalciferol (25-OHD3) by kidney 1-hydroxylase. To test this hypothesis, dihydrotachysterol3 (DHT3), a steroid not requiring 1-hydroxylation for biological activity, was given to chicks as the only source of vitamin D-activity. As expected, DHT3-treated chicks did not adapt to a calcium-deficient diet. However, both the efficiency of Ca absorption and net synthesis of CaBP were stimulated in DHT3-treated chicks by a low phosphorus intake, providing evidence for an alternate pathway of control. © 1973.
Scientific Publication
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