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Gastroenterology (journal)

Israel Gotsman, Arnon Nagler, Roy Beinart, Uri Abadi, Elazar, Rabbani, Dean Engelhardt, Yaron Ilan

Background: In chronic graft versus host disease (cGVHD) an immune attack by
transplanted donor lymphocytes results in inflammatory damage. Immune
hyporesponsiveness induced by oral antigen administration has been shown to suppress
immune-mediated-disorders. Aim: To evaluate the efficacy on cGVHD of oral tolerization
prior to or following transplantation. Methods: cGVHD was generated by infusing 2.5 xlO
splenocytes from BIO. D2 donor mice, to sublethally irradiated (6Gy) Balb/C recipient mice …

P. A357

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Induction of oral tolerance prior to or following bone marrow transplantation ameliorates chronic graft versus host disease in a murine model [abstract]
118, issue 4, part 1

Israel Gotsman, Arnon Nagler, Roy Beinart, Uri Abadi, Elazar, Rabbani, Dean Engelhardt, Yaron Ilan

Background: In chronic graft versus host disease (cGVHD) an immune attack by
transplanted donor lymphocytes results in inflammatory damage. Immune
hyporesponsiveness induced by oral antigen administration has been shown to suppress
immune-mediated-disorders. Aim: To evaluate the efficacy on cGVHD of oral tolerization
prior to or following transplantation. Methods: cGVHD was generated by infusing 2.5 xlO
splenocytes from BIO. D2 donor mice, to sublethally irradiated (6Gy) Balb/C recipient mice …

P. A357

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