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Avian Leptin: Bird's-Eye View of the Evolution of Vertebrate Energy-Balance Control
Year:
2019
Authors :
Friedman-Einat, Miriam
;
.
Seroussi, Eyal
;
.
Volume :
30
Co-Authors:
Facilitators :
From page:
819
To page:
832
(
Total pages:
14
)
Abstract:

Discovery of the satiety hormone leptin in 1994 and its characterization in mammals provided a key tool to deciphering the complex mechanism governing adipose tissue regulation of appetite and energy expenditure. Surprisingly, despite the perfectly logical notion of an energy-storing tissue announcing the amount of fat stores using leptin signaling, alternate mechanisms were chosen in bird evolution. This conclusion emerged based on the recent discovery and characterization of genuine avian leptin – after it had been assumed missing by some, and erroneously identified by others. Critical evaluation of the past and present indications of the role of leptin in Aves provides a new perspective on the evolution of energy-balance control in vertebrates; proposing a regulation strategy alternative to the adipostat mechanism

Note:
Related Files :
Avian
bird
energy-balance contro
energy balance
Evolution
Leptin
vertebrate
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More details
DOI :
Article number:
0
Affiliations:
Database:
Scopus
Publication Type:
article
;
.
Language:
English
Editors' remarks:
ID:
43203
Last updated date:
02/03/2022 17:27
Creation date:
13/08/2019 13:14
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Scientific Publication
Avian Leptin: Bird's-Eye View of the Evolution of Vertebrate Energy-Balance Control
30
Avian Leptin: Bird's-Eye View of the Evolution of Vertebrate Energy-Balance Control

Discovery of the satiety hormone leptin in 1994 and its characterization in mammals provided a key tool to deciphering the complex mechanism governing adipose tissue regulation of appetite and energy expenditure. Surprisingly, despite the perfectly logical notion of an energy-storing tissue announcing the amount of fat stores using leptin signaling, alternate mechanisms were chosen in bird evolution. This conclusion emerged based on the recent discovery and characterization of genuine avian leptin – after it had been assumed missing by some, and erroneously identified by others. Critical evaluation of the past and present indications of the role of leptin in Aves provides a new perspective on the evolution of energy-balance control in vertebrates; proposing a regulation strategy alternative to the adipostat mechanism

Scientific Publication
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