נגישות
menu      
Advanced Search
Syntax
Search...
Volcani treasures
About
Terms of use
Manage
Community:
אסיף מאגר המחקר החקלאי
Powered by ClearMash Solutions Ltd -
Microglial TLR9: Plausible Novel Target for Therapeutic Regime Against Glioblastoma Multiforme
Year:
2020
Authors :
Volume :
41
Co-Authors:

Rohit Kumar Tiwari  - Department of Biosciences, Integral University, Kursi Road, Lucknow, Uttar Pradesh, 226026, India.
Sarika Singh  - Division of Toxicology, CSIR-Central Drug Research Institute, B.S. 10/1, Sector-10, Jankipuram Extension, Lucknow, Uttar Pradesh, 226031, India. 
Chhedi Lal Gupta  - Institute of Soil, Water and Environmental Sciences, Volcani Research Center, ARO, 68 HaMacabim Rd, P.O Box 15159, 7528809, Rishon Lezion, Israel
. 
Preeti Bajpai  - Department of Biosciences, Integral University, Kursi Road, Lucknow, Uttar Pradesh, 226026, India; Department of Zoology, Mahatma Gandhi Central University, Motihari, East Champaran, Bihar, 845401, India.

Facilitators :
From page:
1391
To page:
1393
(
Total pages:
3
)
Abstract:

An understanding of pattern recognition receptors (PRRs) and immunomodulatory approach based on activation of these receptors has provided insights critical for the management of neurological health disorders. Toll-like receptors (TLRs) are one of the most widely explored PRRs and have been exploited in the recent past for development of novel immunomodulatory therapeutic agents. Glioblastoma multiforme is characterized by significant infiltration of resident microglia and expresses all the members of the TLR family. The present report is focused on exciting findings pertaining to probable implications of TLR9 activation by unmethylated CG sequences for novel therapeutic intervention against glioblastoma multiforme, which could be a discrete step toward the effective management of neurological health issues.

Note:
Related Files :
CpG DNA
Glioblastoma multiforme
M2 macrophages
microglia
Toll-Like Receptor 9
Show More
Related Content
More details
DOI :
10.1007/s10571-020-00925-z
Article number:
0
Affiliations:
Database:
PubMed
Publication Type:
Review
;
.
Language:
English
Editors' remarks:
ID:
48709
Last updated date:
20/03/2022 10:56
Creation date:
27/07/2020 17:38
You may also be interested in
Scientific Publication
Microglial TLR9: Plausible Novel Target for Therapeutic Regime Against Glioblastoma Multiforme
41

Rohit Kumar Tiwari  - Department of Biosciences, Integral University, Kursi Road, Lucknow, Uttar Pradesh, 226026, India.
Sarika Singh  - Division of Toxicology, CSIR-Central Drug Research Institute, B.S. 10/1, Sector-10, Jankipuram Extension, Lucknow, Uttar Pradesh, 226031, India. 
Chhedi Lal Gupta  - Institute of Soil, Water and Environmental Sciences, Volcani Research Center, ARO, 68 HaMacabim Rd, P.O Box 15159, 7528809, Rishon Lezion, Israel
. 
Preeti Bajpai  - Department of Biosciences, Integral University, Kursi Road, Lucknow, Uttar Pradesh, 226026, India; Department of Zoology, Mahatma Gandhi Central University, Motihari, East Champaran, Bihar, 845401, India.

Microglial TLR9: Plausible Novel Target for Therapeutic Regime Against Glioblastoma Multiforme

An understanding of pattern recognition receptors (PRRs) and immunomodulatory approach based on activation of these receptors has provided insights critical for the management of neurological health disorders. Toll-like receptors (TLRs) are one of the most widely explored PRRs and have been exploited in the recent past for development of novel immunomodulatory therapeutic agents. Glioblastoma multiforme is characterized by significant infiltration of resident microglia and expresses all the members of the TLR family. The present report is focused on exciting findings pertaining to probable implications of TLR9 activation by unmethylated CG sequences for novel therapeutic intervention against glioblastoma multiforme, which could be a discrete step toward the effective management of neurological health issues.

Scientific Publication
You may also be interested in