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ctsGE—clustering subgroups of expression data
Year:
2017
Source of publication :
Bioinformatics (Oxford, England)
Authors :
Ophir, Ron
;
.
Or, Etti
;
.
Schwager, Michal Sharabi
;
.
Volume :
33
Co-Authors:
Facilitators :
From page:
2053
To page:
2055
(
Total pages:
3
)
Abstract:

A pre-requisite to clustering noisy data, such as gene-expression data, is the filtering step. As an alternative to this step, the ctsGE R-package applies a sorting step in which all of the data are divided into small groups. The groups are divided according to how the time points are related to the time-series median. Then clustering is performed separately on each group. Thus, the clustering is done in two steps. First, an expression index (i.e. a sequence of 1, −1 and 0) is defined and genes with the same index are grouped together, and then each group of genes is clustered by k-means to create subgroups. The ctsGE package also provides an interactive tool to visualize and explore the gene-expression patterns and their subclusters. ctsGE proposes a way of organizing and exploring expression data without eliminating valuable information.

Note:
Related Files :
bioinformatics
bioinformatics
Clustering
Expression data
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More details
DOI :
https://doi.org/10.1093/bioinformatics/btx116
Article number:
0
Affiliations:
Database:
Publication Type:
article
;
.
Language:
English
Editors' remarks:
ID:
49505
Last updated date:
02/03/2022 17:27
Creation date:
03/09/2020 12:05
Scientific Publication
ctsGE—clustering subgroups of expression data
33
ctsGE—clustering subgroups of expression data

A pre-requisite to clustering noisy data, such as gene-expression data, is the filtering step. As an alternative to this step, the ctsGE R-package applies a sorting step in which all of the data are divided into small groups. The groups are divided according to how the time points are related to the time-series median. Then clustering is performed separately on each group. Thus, the clustering is done in two steps. First, an expression index (i.e. a sequence of 1, −1 and 0) is defined and genes with the same index are grouped together, and then each group of genes is clustered by k-means to create subgroups. The ctsGE package also provides an interactive tool to visualize and explore the gene-expression patterns and their subclusters. ctsGE proposes a way of organizing and exploring expression data without eliminating valuable information.

Scientific Publication
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