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Journal of Animal Science

E. Lipkin

Ecological and economic concerns drive the need to improve feed utilization by domestic animals. Residual Feed Intake (RFI) is one of the most acceptable measures for feed efficiency (FE). However, phenotyping RFI related traits is complex, expensive, and requires special equipment. Advances in marker technology allow the development of various DNA-based selection tools. To assimilate these technologies for the benefit of RFI-based selection, reliable phenotypic measures are prerequisite. In the current study, we used genomic DNA of individuals presenting RFI phenotypic consistency across different ages and diets (stages 1–3), for targeted sequencing of chromosomal regions associated with FE and RFI related traits. Forty-eight top single nucleotide polymorphisms (SNPs), significantly associated with at least one of three stages were identified. Eleven of these SNPs were harbored by the fatty acid binding protein 4 (FABP4). While ten significant SNPs found in FABP4, were common for stage 1 and stage 3, one SNP (FABP4_5; A < G substitution), in the promoter region of the gene, was significantly associated with all three stages. As the three stages reflect changing diets and ages with concomitant RFI phenotypic consistency, the above polymorphisms and in particular FABP4_5, might be considered possible markers for RFI-based selection for FE in the Holstein breed, following a larger scale validation.

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P5022: Identification of genetic markers associated with feeding efficiency in fattening Holstein calves, using targeted sequence capture
94, suppl. 4

E. Lipkin

P5022 Identification of genetic markers associated with feeding efficiency in fattening Holstein calves, using targeted sequence capture

Ecological and economic concerns drive the need to improve feed utilization by domestic animals. Residual Feed Intake (RFI) is one of the most acceptable measures for feed efficiency (FE). However, phenotyping RFI related traits is complex, expensive, and requires special equipment. Advances in marker technology allow the development of various DNA-based selection tools. To assimilate these technologies for the benefit of RFI-based selection, reliable phenotypic measures are prerequisite. In the current study, we used genomic DNA of individuals presenting RFI phenotypic consistency across different ages and diets (stages 1–3), for targeted sequencing of chromosomal regions associated with FE and RFI related traits. Forty-eight top single nucleotide polymorphisms (SNPs), significantly associated with at least one of three stages were identified. Eleven of these SNPs were harbored by the fatty acid binding protein 4 (FABP4). While ten significant SNPs found in FABP4, were common for stage 1 and stage 3, one SNP (FABP4_5; A < G substitution), in the promoter region of the gene, was significantly associated with all three stages. As the three stages reflect changing diets and ages with concomitant RFI phenotypic consistency, the above polymorphisms and in particular FABP4_5, might be considered possible markers for RFI-based selection for FE in the Holstein breed, following a larger scale validation.

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