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CRISPR based development of RNA editing and the diagnostic platform
Year:
2021
Authors :
Volume :
Co-Authors:
  • Satish, L.
  • Lavanya, G.
  • Kasthuri, T.
  • Kalaivaani, A.
    Shamili, S.
  • Muthuramalingam, P.
  • Gowrishankar, S.
  • Pandian, S.K.
  • Singh, V.
  • Sitrit, Y.
  • Kushmaro, A.
Facilitators :
From page:
0
To page:
0
(
Total pages:
1
)
Abstract:

Clustered Regularly Interspersed Short Palindromic Repeat-CRISPR-Associated (CRISPR-Cas) system has improved the ability to edit and control gene expression as desired. Genome editing approaches are currently leading the biomedical research with improved focus on direct nuclease dependent editing. So far, the research was predominantly intended on genome editing over the DNA level, recent adapted techniques are initiating to secure momentum through their proficiency to provoke modifications in RNA sequence. Integration of this system besides to lateral flow method allows reliable, quick, sensitive, precise and inexpensive diagnostic. These interesting methods illustrate only a small proportion of what is technically possible for this novel technology, but several technological obstacles need to be overcome prior to the CRISPR-Cas genome editing system can meet its full ability. This chapter covers the particulars on recent advances in CRISPR-Cas9 genome editing technology including diagnosis and technical advancements, followed by molecular mechanism of CRISPR-based RNA editing and diagnostic tools and types, and CRISPR-Cas-based biosensors.

Note:
Related Files :
Biosensors
CRISPR-Cas Systems
genome editing
Non-coding RNA
Targeted gene repair
Show More
Related Content
More details
DOI :
10.1016/bs.pmbts.2020.12.015
Article number:
0
Affiliations:
Database:
Scopus
Publication Type:
Article in press
;
.
Language:
English
Editors' remarks:
ID:
53954
Last updated date:
02/03/2022 17:27
Creation date:
08/03/2021 00:35
Scientific Publication
CRISPR based development of RNA editing and the diagnostic platform
  • Satish, L.
  • Lavanya, G.
  • Kasthuri, T.
  • Kalaivaani, A.
    Shamili, S.
  • Muthuramalingam, P.
  • Gowrishankar, S.
  • Pandian, S.K.
  • Singh, V.
  • Sitrit, Y.
  • Kushmaro, A.

Clustered Regularly Interspersed Short Palindromic Repeat-CRISPR-Associated (CRISPR-Cas) system has improved the ability to edit and control gene expression as desired. Genome editing approaches are currently leading the biomedical research with improved focus on direct nuclease dependent editing. So far, the research was predominantly intended on genome editing over the DNA level, recent adapted techniques are initiating to secure momentum through their proficiency to provoke modifications in RNA sequence. Integration of this system besides to lateral flow method allows reliable, quick, sensitive, precise and inexpensive diagnostic. These interesting methods illustrate only a small proportion of what is technically possible for this novel technology, but several technological obstacles need to be overcome prior to the CRISPR-Cas genome editing system can meet its full ability. This chapter covers the particulars on recent advances in CRISPR-Cas9 genome editing technology including diagnosis and technical advancements, followed by molecular mechanism of CRISPR-based RNA editing and diagnostic tools and types, and CRISPR-Cas-based biosensors.

Scientific Publication
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