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Dietary broccoli improves markers associated with glucose and lipid metabolism through modulation of gut microbiota in mice
Year:
2021
Source of publication :
nutrition
Authors :
Sela, Noa
;
.
Volume :
Co-Authors:

Gil Zandani 
Noga Kaftori-Sandler 
Noa Sela 
Abraham Nyska 
Zecharia Madar              

Facilitators :
From page:
0
To page:
0
(
Total pages:
1
)
Abstract:

Objective: Broccoli is a "functional food" that contains bioactive compounds and phytochemicals that have beneficial health-promoting effects. This study aimed at investigating the effects of broccoli consumption on lipid and glucose metabolism and gut microbiota.

Methods: Male C57BL/6J mice (7-8 wk old) were fed ad libitum with a normal diet supplemented with or without 10% (w/w) broccoli florets or broccoli stalks. Oral glucose tolerance tests were performed at week 15. After 17 wk, blood and tissues were collected. Serum parameters, histology, gene and protein expression, and intestinal microbiota composition were evaluated.

Results: Stalk supplementation led to reductions in fasting glucose levels, serum insulin, and the homeostasis model assessment-insulin resistance (HOMA-IR) index. Liver enzymes improved in both experimental groups, and broccoli florets decreased total triacylglycerols. The stalks group had elevated fatty acid oxidation-related genes and proteins (AMPK, PPARα, and CPT1). Diverse microbiota populations were observed in both broccoli groups. Broccoli stalks were found to be richer in Akkermansia muciniphila, while broccoli florets reduced Mucispirillum schaedleri abundance and increased bacterial richness.

Conclusions: Long-term whole broccoli supplementation decreased inflammation, improved lipid parameters and insulin sensitivity, and altered the gut microbiome in mice. Our data provide new information regarding the potential benefits of broccoli stalks in metabolic parameters.

Note:
Related Files :
AMPK
broccoli
Fatty acid oxidation
Gut microbiota
insulin sensitivity
Show More
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More details
DOI :
10.1016/j.nut.2021.111240
Article number:
111240
Affiliations:
Database:
PubMed
Publication Type:
article
;
.
Language:
English
Editors' remarks:
ID:
54832
Last updated date:
02/03/2022 17:27
Creation date:
04/05/2021 14:28
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Scientific Publication
Dietary broccoli improves markers associated with glucose and lipid metabolism through modulation of gut microbiota in mice

Gil Zandani 
Noga Kaftori-Sandler 
Noa Sela 
Abraham Nyska 
Zecharia Madar              

Dietary broccoli improves markers associated with glucose and lipid metabolism through modulation of gut microbiota in mice

Objective: Broccoli is a "functional food" that contains bioactive compounds and phytochemicals that have beneficial health-promoting effects. This study aimed at investigating the effects of broccoli consumption on lipid and glucose metabolism and gut microbiota.

Methods: Male C57BL/6J mice (7-8 wk old) were fed ad libitum with a normal diet supplemented with or without 10% (w/w) broccoli florets or broccoli stalks. Oral glucose tolerance tests were performed at week 15. After 17 wk, blood and tissues were collected. Serum parameters, histology, gene and protein expression, and intestinal microbiota composition were evaluated.

Results: Stalk supplementation led to reductions in fasting glucose levels, serum insulin, and the homeostasis model assessment-insulin resistance (HOMA-IR) index. Liver enzymes improved in both experimental groups, and broccoli florets decreased total triacylglycerols. The stalks group had elevated fatty acid oxidation-related genes and proteins (AMPK, PPARα, and CPT1). Diverse microbiota populations were observed in both broccoli groups. Broccoli stalks were found to be richer in Akkermansia muciniphila, while broccoli florets reduced Mucispirillum schaedleri abundance and increased bacterial richness.

Conclusions: Long-term whole broccoli supplementation decreased inflammation, improved lipid parameters and insulin sensitivity, and altered the gut microbiome in mice. Our data provide new information regarding the potential benefits of broccoli stalks in metabolic parameters.

Scientific Publication
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