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Tropane alkaloid biosynthesis in Datura innoxia Mill. roots and their differential transport to shoots
Year:
2021
Source of publication :
Phytochemistry Letters
Authors :
Davidovich-Rikanati, Rachel
;
.
Doron-Faigenboim, Adi
;
.
Lewinsohn, Efraim
;
.
Volume :
43
Co-Authors:

Daniel Schlesinger
Rachel Davidovich Rikanati
Adi Faigenboim
Vera Vendramin
Federica Cattonaro
Moshe Inbar
Efraim Lewinsohn

Facilitators :
From page:
0
To page:
0
(
Total pages:
1
)
Abstract:

Pharmacologically important tropane alkaloids such as hyoscyamine, and scopolamine, are synthesized in the roots of several Solanaceae and also accumulate in their shoots. The tropane alkaloids content in roots of D. innoxia seedlings was almost 3-fold higher than in their shoots. Moreover, scopolamine accounted for 77 % of the total tropane alkaloid content in shoots as compared to only 20 % in roots. All candidate genes in the scopolamine biosynthetic pathway were significantly expressed in D. innoxia mature roots with limited expression in mature leaves. Using exogenous isotopically labeled 2H5 L-phenylalanine, we show here that root tissues, but not detached shoots, readily biosynthesize scopolamine. Tropane alkaloids newly synthesized by roots, and preferentially scopolamine, were further transported to shoots. Our evidence indicates that D. innoxia seedlings have the ability to synthesize tropane alkaloids in their roots and differentially transport them to the shoots.

Note:
Related Files :
Anisodamine
Datura innoxia
Hyoscyamine
Littorine
Scopolamine
Tropane alkaloid transport
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More details
DOI :
10.1016/j.phytol.2021.04.012
Article number:
0
Affiliations:
Database:
Scopus
Publication Type:
article
;
.
Language:
English
Editors' remarks:
ID:
55141
Last updated date:
02/03/2022 17:27
Creation date:
25/05/2021 17:31
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Scientific Publication
Tropane alkaloid biosynthesis in Datura innoxia Mill. roots and their differential transport to shoots
43

Daniel Schlesinger
Rachel Davidovich Rikanati
Adi Faigenboim
Vera Vendramin
Federica Cattonaro
Moshe Inbar
Efraim Lewinsohn

Tropane alkaloid biosynthesis in Datura innoxia Mill. roots and their differential transport to shoots

Pharmacologically important tropane alkaloids such as hyoscyamine, and scopolamine, are synthesized in the roots of several Solanaceae and also accumulate in their shoots. The tropane alkaloids content in roots of D. innoxia seedlings was almost 3-fold higher than in their shoots. Moreover, scopolamine accounted for 77 % of the total tropane alkaloid content in shoots as compared to only 20 % in roots. All candidate genes in the scopolamine biosynthetic pathway were significantly expressed in D. innoxia mature roots with limited expression in mature leaves. Using exogenous isotopically labeled 2H5 L-phenylalanine, we show here that root tissues, but not detached shoots, readily biosynthesize scopolamine. Tropane alkaloids newly synthesized by roots, and preferentially scopolamine, were further transported to shoots. Our evidence indicates that D. innoxia seedlings have the ability to synthesize tropane alkaloids in their roots and differentially transport them to the shoots.

Scientific Publication
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