תפריט נגישות
ניגודיות עדינהניגודיות גבוהה
מונוכרום
הדגשת קישורים
חסימת אנימציה
פונט קריא
סגור
איפוס הגדרות נגישות
להורדת מודול נגישות חינם תפריט נגישותניגודיות עדינהניגודיות גבוההמונוכרוםהדגשת קישוריםחסימת אנימציהפונט קריאסגוראיפוס הגדרות נגישותלהורדת מודול נגישות חינםEphraim Ezra
Approximately 15% of the couples cannot achieve and complete pregnancy without medical assistance. Approximately 50% of all conceptions end in miscarriage before pregnancy is detected, complicating the study of early abortions in humans. Cattle are a useful model for reproductive processes in women, due to the similarities in the reproductive cycles. The extensive documentation in commercial cattle populations, including estrus and insemination records are available, can be exploited for such research. The mean estrous interval for cattle is 21 days, and most cows that do not conceive at the first insemination are re-inseminated after approximately 21 days. We therefore defined reinsemination between 49 and 100 days after the first insemination as an indicator trait for early abortion. Using genetic and genomic approaches, we identified several significant genomic markers associated with early abortion. The genomic marker that showed the highest impact on the tendency for early abortion was located within the ABCA9 gene, which is found within an ATPbinding cassette (ABC) genes cluster. These genes are the primary active transporters in the human placenta and are essential for embryo implantation and development. We are currently further exploring these findings in an in-vitro fertilization (IVF) system.
Ephraim Ezra
Approximately 15% of the couples cannot achieve and complete pregnancy without medical assistance. Approximately 50% of all conceptions end in miscarriage before pregnancy is detected, complicating the study of early abortions in humans. Cattle are a useful model for reproductive processes in women, due to the similarities in the reproductive cycles. The extensive documentation in commercial cattle populations, including estrus and insemination records are available, can be exploited for such research. The mean estrous interval for cattle is 21 days, and most cows that do not conceive at the first insemination are re-inseminated after approximately 21 days. We therefore defined reinsemination between 49 and 100 days after the first insemination as an indicator trait for early abortion. Using genetic and genomic approaches, we identified several significant genomic markers associated with early abortion. The genomic marker that showed the highest impact on the tendency for early abortion was located within the ABCA9 gene, which is found within an ATPbinding cassette (ABC) genes cluster. These genes are the primary active transporters in the human placenta and are essential for embryo implantation and development. We are currently further exploring these findings in an in-vitro fertilization (IVF) system.
