One of the most significant factors for the global food crisis is grain losses during storage caused by pest insects, which may reach 30-40%. Today, there are two main chemical methods for stored product insect pest control: fumigation and grain protection by contact insecticides. For both these methods phyto-sanitarian, healthy and ecological disadvantages are well documented. The global tendency is to prevent/decrease the wide use of common chemical insecticides with high toxicity to humans, especially for control of pests in food. Therefore, there is an urgent need for developing an alternative eco-friendly approach for stored insect pest control, aimed to prevent grain quantity losses and quality degradation of stored food and feed grain and dry food products caused by stored product insect pests. Based on results from our lab and other labs worldwide, we suggest an integrated protection approach as an alternative to the traditional methods of grain pest control. This approach includes prevention measures, systematic inspection and monitoring for grain storage risk factors; the use of eco-friendly volatiles and protectants; and improved technologies for currently used fumigants. The implementation of this approach in Israel resulted in a dramatic reduction in stored grain losses to < 0.5%.