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Spinal dI2 interneurons regulate the stability of bipedal stepping
Year:
2020
Authors :
Cinnamon, Yuval
;
.
Volume :
Co-Authors:

Baruch Haimson, Yoav Hadas, Artur Kania, Monica Daley, Aharon Lev-Tov, Avihu Klar

Facilitators :
From page:
0
To page:
0
(
Total pages:
1
)
Abstract:

Peripheral and intraspinal feedback is required to shape and update the output of spinal networks that execute motor behavior. We report that lumbar dI2 spinal interneurons of the chick receive synaptic input from afferents and pre-motoneurons. They innervate contralateral premotor networks in the lumbar and brachial spinal cord and their ascending projections innervate the cerebellum. These findings suggest that dI2 neurons function as interneurons in local lumbar circuits and involved in lumbo-brachial coupling and that part of them deliver peripheral and intraspinal feedback to the cerebellum. Silencing of dI2 neurons leads to destabilized stepping in P8 hatchlings with occasional collapses, variable step-profiles and wide-base walking, suggesting that the dI2 neurons may contribute to stabilization of the bipedal gait.

Note:
Related Files :
animal physiology
chicks
motor performance
Neurons
poultry
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DOI :
https://doi.org/10.1101/2020.01.07.898072
Article number:
0
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Database:
Publication Type:
article
;
.
Language:
English
Editors' remarks:
ID:
55918
Last updated date:
02/03/2022 17:27
Creation date:
16/08/2021 11:17
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Scientific Publication
Spinal dI2 interneurons regulate the stability of bipedal stepping

Baruch Haimson, Yoav Hadas, Artur Kania, Monica Daley, Aharon Lev-Tov, Avihu Klar

Spinal dI2 interneurons regulate the stability of bipedal stepping

Peripheral and intraspinal feedback is required to shape and update the output of spinal networks that execute motor behavior. We report that lumbar dI2 spinal interneurons of the chick receive synaptic input from afferents and pre-motoneurons. They innervate contralateral premotor networks in the lumbar and brachial spinal cord and their ascending projections innervate the cerebellum. These findings suggest that dI2 neurons function as interneurons in local lumbar circuits and involved in lumbo-brachial coupling and that part of them deliver peripheral and intraspinal feedback to the cerebellum. Silencing of dI2 neurons leads to destabilized stepping in P8 hatchlings with occasional collapses, variable step-profiles and wide-base walking, suggesting that the dI2 neurons may contribute to stabilization of the bipedal gait.

Scientific Publication
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