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Antiviral Polymers Based on N-Halamine Polyurea
Year:
2021
Source of publication :
Biomacromolecules
Authors :
Dombrovsky, Aviv
;
.
Volume :
Co-Authors:
  • Noam Y. Steinman, 
  • Tan Hu, 
  • Aviv Dombrovsky, 
  • Meital Reches,  
  • Abraham J. Domb
Facilitators :
From page:
0
To page:
0
(
Total pages:
1
)
Abstract:

N-halamines are a commonly applied class of antimicrobial agents used for a variety of applications relating to human health. Here, we present the modulation of the common polymers polyurea and polyguanidine with the N-halamine technology. The N–H bonds in either polymer were converted to N–Cl or N–Br bonds capable of releasing Cl+ or Br+ cations to aqueous media as antiviral agents. Controlled release of the oxidizing agents was monitored for a period of 4 weeks. Antiviral activity was evaluated against the T4 bacteriophage as well as against the highly stable plant virus belonging to the Tobamovirus genus, tomato brown rugose fruit virus. The incorporation of the N-halamine technology on commonly used polymers has effectively introduced antiviral functionality for a wide variety of potential applications.

Note:
Related Files :
Antimicrobial agents
Guanidine
Polymers
Urea
Viruses
Show More
Related Content
More details
DOI :
10.1021/acs.biomac.1c00920
Article number:
0
Affiliations:
Database:
Scopus
Publication Type:
article
;
.
Language:
English
Editors' remarks:
ID:
56581
Last updated date:
02/03/2022 17:27
Creation date:
12/10/2021 16:06
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Scientific Publication
Antiviral Polymers Based on N-Halamine Polyurea
  • Noam Y. Steinman, 
  • Tan Hu, 
  • Aviv Dombrovsky, 
  • Meital Reches,  
  • Abraham J. Domb
Antiviral Polymers Based on N-Halamine Polyurea

N-halamines are a commonly applied class of antimicrobial agents used for a variety of applications relating to human health. Here, we present the modulation of the common polymers polyurea and polyguanidine with the N-halamine technology. The N–H bonds in either polymer were converted to N–Cl or N–Br bonds capable of releasing Cl+ or Br+ cations to aqueous media as antiviral agents. Controlled release of the oxidizing agents was monitored for a period of 4 weeks. Antiviral activity was evaluated against the T4 bacteriophage as well as against the highly stable plant virus belonging to the Tobamovirus genus, tomato brown rugose fruit virus. The incorporation of the N-halamine technology on commonly used polymers has effectively introduced antiviral functionality for a wide variety of potential applications.

Scientific Publication
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