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An insight into the molecular docking interactions of plant secondary metabolites with virulent factors causing common human diseases
Year:
2021
Source of publication :
South African Journal of Botany
Authors :
Kumar, Ajay
;
.
Volume :
Co-Authors:

Ajay Kumar
Sandeep Kumar Singh
Vipin Kumar Singh
Chandra Kant
Amit Kishore Singh
Vijay Tripathi
Kalpna Singh
Vijay Kumar Sharma
Joginder Singh

Facilitators :
From page:
0
To page:
0
(
Total pages:
1
)
Abstract:

Plant natural products or secondary metabolites have gained significant attention globally because of discoveries of semi-synthetic drugs novel bioactive compounds. Currently, a large part of global population relies on natural products to cure ailments and even chronic diseases and to enhance their immune system. Interestingly, the commonly used drugs for the treatment of some common human diseases like cancer, ulcer, tuberculosis, asthma, etc., have been reported to be of plant origin and recognized to elicit beneficial effects in virulent factors of diseases in vivo and in vitro. The herbal drugs are economical and considered as safe upto certain extent from major side effects. But, still there is need of rapid collection, characterization, taxonomy, certification, and storage for broad, efficient and effective use in drug design or discovery. In this review, we summarized the plants derived secondary metabolites used in treating common human diseases and emphasised the protein-ligand interactions between virulent factors of diseases namely Insulin, p53, Proteasome-associated ATPase, Enterotoxin, Choleragen, IgE with secondary metabolites Aloin, Sesamin, Alliin, Flavanon, Salannin Octyl-β-d-Glucopyranoside of plants respectively, through molecular docking. This study will play a valuable and effective role in drug designing and screening plant-derived metabolites for drug designing.

Note:
Related Files :
Human diseases
molecular docking
Plant natural products
Secondary metabolites
Virulent factors
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More details
DOI :
Article number:
0
Affiliations:
Database:
Google Scholar
Publication Type:
article
;
.
Language:
English
Editors' remarks:
ID:
57104
Last updated date:
02/03/2022 17:27
Creation date:
30/11/2021 15:12
Scientific Publication
An insight into the molecular docking interactions of plant secondary metabolites with virulent factors causing common human diseases

Ajay Kumar
Sandeep Kumar Singh
Vipin Kumar Singh
Chandra Kant
Amit Kishore Singh
Vijay Tripathi
Kalpna Singh
Vijay Kumar Sharma
Joginder Singh

An insight into the molecular docking interactions of plant secondary metabolites with virulent factors causing common human diseases

Plant natural products or secondary metabolites have gained significant attention globally because of discoveries of semi-synthetic drugs novel bioactive compounds. Currently, a large part of global population relies on natural products to cure ailments and even chronic diseases and to enhance their immune system. Interestingly, the commonly used drugs for the treatment of some common human diseases like cancer, ulcer, tuberculosis, asthma, etc., have been reported to be of plant origin and recognized to elicit beneficial effects in virulent factors of diseases in vivo and in vitro. The herbal drugs are economical and considered as safe upto certain extent from major side effects. But, still there is need of rapid collection, characterization, taxonomy, certification, and storage for broad, efficient and effective use in drug design or discovery. In this review, we summarized the plants derived secondary metabolites used in treating common human diseases and emphasised the protein-ligand interactions between virulent factors of diseases namely Insulin, p53, Proteasome-associated ATPase, Enterotoxin, Choleragen, IgE with secondary metabolites Aloin, Sesamin, Alliin, Flavanon, Salannin Octyl-β-d-Glucopyranoside of plants respectively, through molecular docking. This study will play a valuable and effective role in drug designing and screening plant-derived metabolites for drug designing.

Scientific Publication
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