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אסיף מאגר המחקר החקלאי
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Collisions of Cortical Microtubules with Membrane Associated Myosin VIII Tail
Year:
2022
Source of publication :
Cells
Authors :
Belausov, Eduard
;
.
Sadot, Einat
;
.
Volume :
Co-Authors:

 

Sefi Bar-Sinai

Eduard Belausov

Vikas Dwivedi

 Einat Sadot

 *

Facilitators :
From page:
0
To page:
0
(
Total pages:
1
)
Abstract:

The distribution of myosin VIII ATM1 tail in association with the plasma membrane is often observed in coordination with that of cortical microtubules (MTs). The prevailing hypothesis is that coordination between the organization of cortical MTs and proteins in the membrane results from the inhibition of free lateral diffusion of the proteins by barriers formed by MTs. Since the positioning of myosin VIII tail in the membrane is relatively stable, we ask: can it affect the organization of MTs? Myosin VIII ATM1 tail co-localized with remorin 6.6, the position of which in the plasma membrane is also relatively stable. Overexpression of myosin VIII ATM1 tail led to a larger fraction of MTs with a lower rate of orientation dispersion. In addition, collisions between MTs and cortical structures labeled by ATM1 tail or remorin 6.6 were observed. Collisions between EB1 labeled MTs and ATM1 tail clusters led to four possible outcomes: 1—Passage of MTs through the cluster; 2—Decreased elongation rate; 3—Disengagement from the membrane followed by a change in direction; and 4—retraction. EB1 tracks became straighter in the presence of ATM1 tail. Taken together, collisions of MTs with ATM1 tail labeled structures can contribute to their coordinated organization.

Note:
Related Files :
collisions
Microtubules
myosin VIII
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More details
DOI :
10.3390/cells11010145
Article number:
0
Affiliations:
Database:
Google Scholar
Publication Type:
article
;
.
Language:
English
Editors' remarks:
ID:
57614
Last updated date:
02/03/2022 17:27
Creation date:
12/01/2022 21:59
Scientific Publication
Collisions of Cortical Microtubules with Membrane Associated Myosin VIII Tail

 

Sefi Bar-Sinai

Eduard Belausov

Vikas Dwivedi

 Einat Sadot

 *

Collisions of Cortical Microtubules with Membrane Associated Myosin VIII Tail

The distribution of myosin VIII ATM1 tail in association with the plasma membrane is often observed in coordination with that of cortical microtubules (MTs). The prevailing hypothesis is that coordination between the organization of cortical MTs and proteins in the membrane results from the inhibition of free lateral diffusion of the proteins by barriers formed by MTs. Since the positioning of myosin VIII tail in the membrane is relatively stable, we ask: can it affect the organization of MTs? Myosin VIII ATM1 tail co-localized with remorin 6.6, the position of which in the plasma membrane is also relatively stable. Overexpression of myosin VIII ATM1 tail led to a larger fraction of MTs with a lower rate of orientation dispersion. In addition, collisions between MTs and cortical structures labeled by ATM1 tail or remorin 6.6 were observed. Collisions between EB1 labeled MTs and ATM1 tail clusters led to four possible outcomes: 1—Passage of MTs through the cluster; 2—Decreased elongation rate; 3—Disengagement from the membrane followed by a change in direction; and 4—retraction. EB1 tracks became straighter in the presence of ATM1 tail. Taken together, collisions of MTs with ATM1 tail labeled structures can contribute to their coordinated organization.

Scientific Publication
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