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Spatiotemporal bio-shielding of bacteria through consolidated geometrical structuring
Year:
2022
Source of publication :
npj Biofilms and Microbiomes
Authors :
Shemesh, Moshe
;
.
Volume :
Co-Authors:
  • Satish Kumar Rajasekharan 
  • Moshe Shemesh 
Facilitators :
From page:
0
To page:
0
(
Total pages:
1
)
Abstract:

The probiotic bacterium Lactobacillus plantarum is often reckoned as a ‘generalist’ for its ability to adapt and survive in diverse ecological niches. The genomic signatures of L. plantarum have shown its intricate evolutionary ancestry and dynamic lifestyles. Here, we report on a unique geometrical arrangement of the multicellular population of L. plantarum cells. Prominently, a phenomenon of the cone-shaped colony formation and V-shaped cell chaining are discovered in response to the acidic-pH environment. Moreover, subsequent cold stress response triggers an unusual cellular arrangement of consolidated bundles, which appeared to be independently governed by a small heat shock protein (HSP 1). We further report that the V-shaped L. plantarum chaining demonstrates potent antagonistic activity against Candida albicans, a pathogenic yeast, both in vitro and in a Caenorhabditis elegans co-infection model. Finally, we deduce that the multifaceted traits manifested by this probiotic bacterium is an outcome of its dynamic flexibility and cellular heterogeneity.

Note:
Related Files :
Applied microbiology
Biofilms
Microbial communities
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More details
DOI :
10.1038/s41522-022-00302-2
Article number:
0
Affiliations:
Database:
Scopus
Publication Type:
article
;
.
Language:
English
Editors' remarks:
ID:
59002
Last updated date:
22/05/2022 14:50
Creation date:
22/05/2022 14:50
Scientific Publication
Spatiotemporal bio-shielding of bacteria through consolidated geometrical structuring
  • Satish Kumar Rajasekharan 
  • Moshe Shemesh 
Spatiotemporal bio-shielding of bacteria through consolidated geometrical structuring

The probiotic bacterium Lactobacillus plantarum is often reckoned as a ‘generalist’ for its ability to adapt and survive in diverse ecological niches. The genomic signatures of L. plantarum have shown its intricate evolutionary ancestry and dynamic lifestyles. Here, we report on a unique geometrical arrangement of the multicellular population of L. plantarum cells. Prominently, a phenomenon of the cone-shaped colony formation and V-shaped cell chaining are discovered in response to the acidic-pH environment. Moreover, subsequent cold stress response triggers an unusual cellular arrangement of consolidated bundles, which appeared to be independently governed by a small heat shock protein (HSP 1). We further report that the V-shaped L. plantarum chaining demonstrates potent antagonistic activity against Candida albicans, a pathogenic yeast, both in vitro and in a Caenorhabditis elegans co-infection model. Finally, we deduce that the multifaceted traits manifested by this probiotic bacterium is an outcome of its dynamic flexibility and cellular heterogeneity.

Scientific Publication
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