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Entourage effect for phenolic compounds on production and metabolism of mammary epithelial cells
Year:
2022
Source of publication :
Heliyon
Authors :
Deutch, Tova
;
.
Landau, Serge Yan
;
.
Muklada, Hussein
;
.
Volume :
Co-Authors:

Y Shalev 
O Hadaya
R Bransi-Nicola 
S Y Landau
H Azaizeh
H Muklada
T Glasser
Z Roth
T Deutch-Traubman
M Haj-Zaroubi
N Argov-Argaman

Facilitators :
From page:
0
To page:
0
(
Total pages:
1
)
Abstract:

Primary culture of mammary epithelial cells (MEC) was exposed to ethyl-acetate, chloroform and hexane extracts of Pistacia lentiscus (lentisk). The hexane extract contained mainly ethyl gallate whereas the chloroform extract contained mainly ethyl-gallate with smaller amount of gallic acid, and the ethyl-acetate extract contained mainly rutin, gallic acid and myricetin. Ethyl acetate extract increased secretion of protein and fat and improved mitochondrial activity. The enhancing effect on protein production was attributed to myricetin, one of the polyphenols in the ethyl-acetate extract whereas gallic acid did not affect protein production or secretion. Interestingly, exposure to the isolated polyphenols did not improve mitochondrial productivity and activity as effectively as exposure to the complete plant extract. The results indicated that polyphenols improve production of milk constituents by MEC, through different modes of action for different polyphenols suggesting an additive or even synergistic effect on production traits of mammary cells.

Note:
Related Files :
casein
Mammary gland
milk
polyphenol
triglyceride
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More details
DOI :
10.1016/j.heliyon.2022.e09025
Article number:
0
Affiliations:
Database:
PubMed
Publication Type:
article
;
.
Language:
English
Editors' remarks:
ID:
61678
Last updated date:
30/08/2022 14:18
Creation date:
30/08/2022 13:35
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Scientific Publication
Entourage effect for phenolic compounds on production and metabolism of mammary epithelial cells

Y Shalev 
O Hadaya
R Bransi-Nicola 
S Y Landau
H Azaizeh
H Muklada
T Glasser
Z Roth
T Deutch-Traubman
M Haj-Zaroubi
N Argov-Argaman

Entourage effect for phenolic compounds on production and metabolism of mammary epithelial cells

Primary culture of mammary epithelial cells (MEC) was exposed to ethyl-acetate, chloroform and hexane extracts of Pistacia lentiscus (lentisk). The hexane extract contained mainly ethyl gallate whereas the chloroform extract contained mainly ethyl-gallate with smaller amount of gallic acid, and the ethyl-acetate extract contained mainly rutin, gallic acid and myricetin. Ethyl acetate extract increased secretion of protein and fat and improved mitochondrial activity. The enhancing effect on protein production was attributed to myricetin, one of the polyphenols in the ethyl-acetate extract whereas gallic acid did not affect protein production or secretion. Interestingly, exposure to the isolated polyphenols did not improve mitochondrial productivity and activity as effectively as exposure to the complete plant extract. The results indicated that polyphenols improve production of milk constituents by MEC, through different modes of action for different polyphenols suggesting an additive or even synergistic effect on production traits of mammary cells.

Scientific Publication
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