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The global distribution and environmental drivers of the soil antibiotic resistome
Year:
2022
Source of publication :
microbiome
Authors :
Zaady, Eli
;
.
Volume :
Co-Authors:

Manuel Delgado-Baquerizo, 
Hang-Wei Hu, 
Fernando T. Maestre, 
Carlos A. Guerra,
Nico Eisenhauer, 
David J. Eldridge, 
Yong-Guan Zhu, 
Qing-Lin Chen,
 Pankaj Trivedi, 
Shuai Du, 
Thulani P. Makhalanyane, 
Jay P. Verma, 
Beatriz Gozalo, 
Victoria Ochoa, 
Sergio Asensio, 
Ling Wang, 
Eli Zaady,
Javier G. Illán, 
Christina Siebe, 
Tine Grebenc,
 Xiaobing Zhou, 
Yu-Rong Liu, 
Adebola R. Bamigboye, 
José L. Blanco-Pastor, 
Jorge Duran, 
Alexandra Rodríguez, 
Steven Mamet, 
Fernando Alfaro, 
Sebastian Abades, 
Alberto L. Teixido, 
Gabriel F. Peñaloza-Bojacá, 
Marco Molina-Montenegro, 
Cristian Torres-Díaz, 
Cecilia Perez, 
Antonio Gallardo, 
Laura García-Velázquez, 
Patrick E. Hayes, 
Sigrid Neuhauser, 
Ji-Zheng He

Facilitators :
From page:
0
To page:
0
(
Total pages:
1
)
Abstract:

Background
Little is known about the global distribution and environmental drivers of key microbial functional traits such as antibiotic resistance genes (ARGs). Soils are one of Earth’s largest reservoirs of ARGs, which are integral for soil microbial competition, and have potential implications for plant and human health. Yet, their diversity and global patterns remain poorly described. Here, we analyzed 285 ARGs in soils from 1012 sites across all continents and created the first global atlas with the distributions of topsoil ARGs.


Results
We show that ARGs peaked in high latitude cold and boreal forests. Climatic seasonality and mobile genetic elements, associated with the transmission of antibiotic resistance, were also key drivers of their global distribution. Dominant ARGs were mainly related to multidrug resistance genes and efflux pump machineries. We further pinpointed the global hotspots of the diversity and proportions of soil ARGs.


Conclusions
Together, our work provides the foundation for a better understanding of the ecology and global distribution of the environmental soil antibiotic resistome.

Note:
Related Files :
antibiotic resistance
Global change
Human health
Mobile genetic element
Show More
Related Content
More details
DOI :
10.1186/s40168-022-01405-w
Article number:
0
Affiliations:
Database:
Scopus
Publication Type:
article
;
.
Language:
English
Editors' remarks:
ID:
62855
Last updated date:
25/12/2022 14:55
Creation date:
25/12/2022 14:55
You may also be interested in
Scientific Publication
The global distribution and environmental drivers of the soil antibiotic resistome

Manuel Delgado-Baquerizo, 
Hang-Wei Hu, 
Fernando T. Maestre, 
Carlos A. Guerra,
Nico Eisenhauer, 
David J. Eldridge, 
Yong-Guan Zhu, 
Qing-Lin Chen,
 Pankaj Trivedi, 
Shuai Du, 
Thulani P. Makhalanyane, 
Jay P. Verma, 
Beatriz Gozalo, 
Victoria Ochoa, 
Sergio Asensio, 
Ling Wang, 
Eli Zaady,
Javier G. Illán, 
Christina Siebe, 
Tine Grebenc,
 Xiaobing Zhou, 
Yu-Rong Liu, 
Adebola R. Bamigboye, 
José L. Blanco-Pastor, 
Jorge Duran, 
Alexandra Rodríguez, 
Steven Mamet, 
Fernando Alfaro, 
Sebastian Abades, 
Alberto L. Teixido, 
Gabriel F. Peñaloza-Bojacá, 
Marco Molina-Montenegro, 
Cristian Torres-Díaz, 
Cecilia Perez, 
Antonio Gallardo, 
Laura García-Velázquez, 
Patrick E. Hayes, 
Sigrid Neuhauser, 
Ji-Zheng He

The global distribution and environmental drivers of the soil antibiotic resistome

Background
Little is known about the global distribution and environmental drivers of key microbial functional traits such as antibiotic resistance genes (ARGs). Soils are one of Earth’s largest reservoirs of ARGs, which are integral for soil microbial competition, and have potential implications for plant and human health. Yet, their diversity and global patterns remain poorly described. Here, we analyzed 285 ARGs in soils from 1012 sites across all continents and created the first global atlas with the distributions of topsoil ARGs.


Results
We show that ARGs peaked in high latitude cold and boreal forests. Climatic seasonality and mobile genetic elements, associated with the transmission of antibiotic resistance, were also key drivers of their global distribution. Dominant ARGs were mainly related to multidrug resistance genes and efflux pump machineries. We further pinpointed the global hotspots of the diversity and proportions of soil ARGs.


Conclusions
Together, our work provides the foundation for a better understanding of the ecology and global distribution of the environmental soil antibiotic resistome.

Scientific Publication
You may also be interested in