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Hydrophilic Chitosan Derivatives: Synthesis and Applications
Year:
2022
Source of publication :
Chemistry - A European Journal
Authors :
Poverenov, Elena
;
.
Volume :
Co-Authors:

Erez Cohen 
Elena Poverenov 

Facilitators :
From page:
0
To page:
0
(
Total pages:
1
)
Abstract:

Polymer alternatives sourced from nature have attracted increasing attention for applications in medicine, cosmetics, agriculture, food, water purification, and more. Among them, chitosan is the most versatile due to its full biodegradability, exceptional biocompatibility, multipurpose bioactivity, and low toxicity. Although remarkable progress has been made in its synthetic modification by using C3/C6 secondary/primary hydroxy (-OH) and the C2 amino (-NH2 ) active sites, its solubility under physiological conditions remains limited and has hampered larger-scale adoption. This review summarizes different synthetic methods that increase chitosan's hydrophilicity and water solubility by using covalent modifications, namely amino acid addition, quaternary ammonium formation, phosphorylation, and carboxymethylation. We also review several applications for each type of substitution in fields such as cosmetics, medicine, agriculture, and water purification, and provide an outlook and perspective for future modifications and implementations.

Note:
Related Files :
Antibacterial
Biopolymers
Chitosan
hydrophilic substitution
Nanoparticles
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Related Content
More details
DOI :
10.1002/chem.202202156
Article number:
0
Affiliations:
Database:
PubMed
Publication Type:
article
;
.
Language:
English
Editors' remarks:
ID:
62916
Last updated date:
27/12/2022 16:13
Creation date:
27/12/2022 16:13
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Scientific Publication
Hydrophilic Chitosan Derivatives: Synthesis and Applications

Erez Cohen 
Elena Poverenov 

Hydrophilic Chitosan Derivatives: Synthesis and Applications

Polymer alternatives sourced from nature have attracted increasing attention for applications in medicine, cosmetics, agriculture, food, water purification, and more. Among them, chitosan is the most versatile due to its full biodegradability, exceptional biocompatibility, multipurpose bioactivity, and low toxicity. Although remarkable progress has been made in its synthetic modification by using C3/C6 secondary/primary hydroxy (-OH) and the C2 amino (-NH2 ) active sites, its solubility under physiological conditions remains limited and has hampered larger-scale adoption. This review summarizes different synthetic methods that increase chitosan's hydrophilicity and water solubility by using covalent modifications, namely amino acid addition, quaternary ammonium formation, phosphorylation, and carboxymethylation. We also review several applications for each type of substitution in fields such as cosmetics, medicine, agriculture, and water purification, and provide an outlook and perspective for future modifications and implementations.

Scientific Publication
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