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Nucleoside-Based Cross-Linkers for Hydrogels with Tunable Properties
Year:
2023
Authors :
Fallik, Elazar
;
.
Kleiman, Maya
;
.
Poverenov, Elena
;
.
Volume :
Co-Authors:

Rafael Itzhakov
Dmitry Tworowski
Noy Sadot
Tali Sayas
Elazar Fallik
Maya Kleiman
Elena Poverenov 

Facilitators :
From page:
0
To page:
0
(
Total pages:
1
)
Abstract:

Herein, we report bioderived cross-linkers to create biopolymer-based hydrogels with tunable properties. Nucleosides (inosine and uridine) and ribose (pentose sugar lucking the nitrogenous base) were partially oxidized to yield inosine dialdehyde (IdA), uridine dialdehyde (UdA), and ribose dialdehyde (RdA). The dialdehydes were further used as cross-linkers with polysaccharide chitosan to form hydrogels. Depending on the cross-linker type and concentration, the hydrogels showed tunable rheological, mechanical, and liquid holding properties allowing the preparation of injectable, soft, and moldable hydrogels. Computational modeling and molecular dynamics simulations shed light on hydrogel formation and revealed that, in addition to covalent bonding, noncovalent interactions (π-π stacking, cation-π, and H-bonding) also significantly contributed to the cross-linking process. To demonstrate various application possibilities, the prepared hydrogels were used as a growth platform for plant cells, as injectable inks for layer-by-layer 3D printing applications, and as moldable hydrogels for soft lithography to replicate the microstructure of the plant. These findings suggest that the obtained tunable biocompatible hydrogels have the potential to be good candidates for various biotechnological applications.

Note:
Related Files :
Biocompatibility
Biopolymers
Chitosan
cross-linkers
hydrogel
Nucleosides
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Related Content
More details
DOI :
10.1021/acsami.2c19525
Article number:
0
Affiliations:
Database:
PubMed
Publication Type:
article
;
.
Language:
English
Editors' remarks:
ID:
63346
Last updated date:
01/02/2023 16:59
Creation date:
01/02/2023 16:59
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Scientific Publication
Nucleoside-Based Cross-Linkers for Hydrogels with Tunable Properties

Rafael Itzhakov
Dmitry Tworowski
Noy Sadot
Tali Sayas
Elazar Fallik
Maya Kleiman
Elena Poverenov 

Nucleoside-Based Cross-Linkers for Hydrogels with Tunable Properties

Herein, we report bioderived cross-linkers to create biopolymer-based hydrogels with tunable properties. Nucleosides (inosine and uridine) and ribose (pentose sugar lucking the nitrogenous base) were partially oxidized to yield inosine dialdehyde (IdA), uridine dialdehyde (UdA), and ribose dialdehyde (RdA). The dialdehydes were further used as cross-linkers with polysaccharide chitosan to form hydrogels. Depending on the cross-linker type and concentration, the hydrogels showed tunable rheological, mechanical, and liquid holding properties allowing the preparation of injectable, soft, and moldable hydrogels. Computational modeling and molecular dynamics simulations shed light on hydrogel formation and revealed that, in addition to covalent bonding, noncovalent interactions (π-π stacking, cation-π, and H-bonding) also significantly contributed to the cross-linking process. To demonstrate various application possibilities, the prepared hydrogels were used as a growth platform for plant cells, as injectable inks for layer-by-layer 3D printing applications, and as moldable hydrogels for soft lithography to replicate the microstructure of the plant. These findings suggest that the obtained tunable biocompatible hydrogels have the potential to be good candidates for various biotechnological applications.

Scientific Publication
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