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Phytocannabinoids have cytotoxic, antiproliferative, and antimigratory activities on cancer cells and cancer stem cells
Year:
2023
Authors :
Koltai, Hinanit
;
.
Volume :
Co-Authors:

Hadar Peeri
Hinanit Koltai

Facilitators :
From page:
555
To page:
564
(
Total pages:
10
)
Abstract:

Cannabis sativa produces hundreds of secondary metabolites, including phytocannabinoids, terpenes, and flavonoids. Among the 160 phytocannabinoids identified in C. sativa, Δ9-tetrahydrocannabinol (THC), cannabidiol (CBD), and cannabigerol (CBG) are highly abundant. CBG is abundant mostly in young cannabis plants. When the plant is maturing, most of the CBG is turning into THC/CBD. Cannabis is used worldwide to treat various medical conditions, mostly as palliative care to chronic pain or cancer patients. Yet, numerous studies demonstrated therapeutic properties for cannabis compounds that are mediated by interaction with the endocannabinoid receptors and activation of multiple signaling pathways associated with, e.g., programmed cell death. Phytocannabinoids were shown to have cytotoxic, antiproliferative, and antimigratory effect on cancer cells. These compounds have also cytotoxic activity against cancer stem cells. Moreover, it was demonstrated that certain combinations of phytocannabinoids act synergistically against cancer cells with greater effects than each molecule alone. This chapter presents the therapeutic potential of cannabis compounds in exerting effects on cancer cells, focusing mainly on glioma and glioblastoma stem cells.

Note:
Related Files :
Cancer
cancer stem cell
cannabinoid receptors
Cannabis
cytotoxicity
glioma
Synergy
Show More
Related Content
More details
DOI :
10.1016/B978-0-323-89862-1.00030-1
Article number:
0
Affiliations:
Database:
Scopus
Publication Type:
Book chapter
;
.
Language:
English
Editors' remarks:
ID:
65251
Last updated date:
28/08/2023 18:04
Creation date:
28/08/2023 17:38
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Scientific Publication
Phytocannabinoids have cytotoxic, antiproliferative, and antimigratory activities on cancer cells and cancer stem cells

Hadar Peeri
Hinanit Koltai

Phytocannabinoids have cytotoxic, antiproliferative, and antimigratory activities on cancer cells and cancer stem cells

Cannabis sativa produces hundreds of secondary metabolites, including phytocannabinoids, terpenes, and flavonoids. Among the 160 phytocannabinoids identified in C. sativa, Δ9-tetrahydrocannabinol (THC), cannabidiol (CBD), and cannabigerol (CBG) are highly abundant. CBG is abundant mostly in young cannabis plants. When the plant is maturing, most of the CBG is turning into THC/CBD. Cannabis is used worldwide to treat various medical conditions, mostly as palliative care to chronic pain or cancer patients. Yet, numerous studies demonstrated therapeutic properties for cannabis compounds that are mediated by interaction with the endocannabinoid receptors and activation of multiple signaling pathways associated with, e.g., programmed cell death. Phytocannabinoids were shown to have cytotoxic, antiproliferative, and antimigratory effect on cancer cells. These compounds have also cytotoxic activity against cancer stem cells. Moreover, it was demonstrated that certain combinations of phytocannabinoids act synergistically against cancer cells with greater effects than each molecule alone. This chapter presents the therapeutic potential of cannabis compounds in exerting effects on cancer cells, focusing mainly on glioma and glioblastoma stem cells.

Scientific Publication
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