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An integrated analysis of transcriptome and metabolome reveals three BCAAs relieve lipid accumulation by inhibiting lipid synthesis and promoting lipid oxidation in the liver of largemouth bass (Micropterus salmoides)
Year:
2024
Source of publication :
aquaculture
Authors :
Harpaz, Sheenan
;
.
Volume :
581
Co-Authors:

Qiang Chen
Congcong Wang
Yulong Sun
Songming Chen
Jiaqi Zhou
Tao Han
Jiteng Wang
Sheenan Harpaz 

Facilitators :
From page:
0
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0
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Total pages:
1
)
Abstract:

The intricate and paradoxical relationship between branched-chain amino acids (BCAAs) and lipid metabolism has been focused on the field of nutrition. However, the molecular mechanism mediated by BCAAs in the lipid metabolism of fish is poorly understood. To address this knowledge gap, we characterized the transcriptome and metabolome in the liver of largemouth bass (Micropterus salmoides), an extensively cultivated fish with high commercial value. Dietary BCAA supplementation significantly enhanced growth performance, combined with the elevation of essential amino acid levels and the improvement of liver health. Moreover, enzymatic detection and RT–qPCR results showed that BCAAs decreased lipid deposition in the liver. Integrated transcriptomics and metabolomics analysis revealed that the inhibition of lipid synthesis and enhancement of fatty acid degradation may explain the mechanism by which BCAAs relieved lipid accumulation in the liver. The metabolic enzymes acacaacaa2cpt2acat, and aldh9a1, which were regulated by all three BCAAs, are key targets linking BCAA metabolism and lipid metabolism. Considering that farmed fish suffer from abnormal lipid accumulation in the liver, appropriate BCAA supplementation is an effective nutritional strategy to improve lipid metabolism disorders in aquaculture.

Note:
Related Files :
branched-chain amino acids (BCAAs)
largemouth bass
Lipid oxidation
metabolome
Micropterus salmoides
transcriptome
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More details
DOI :
10.1016/j.aquaculture.2023.740384
Article number:
740384
Affiliations:
Database:
Scopus
Publication Type:
article
;
.
Language:
English
Editors' remarks:
ID:
67336
Last updated date:
12/12/2023 12:26
Creation date:
12/12/2023 12:13
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Scientific Publication
An integrated analysis of transcriptome and metabolome reveals three BCAAs relieve lipid accumulation by inhibiting lipid synthesis and promoting lipid oxidation in the liver of largemouth bass (Micropterus salmoides)
581

Qiang Chen
Congcong Wang
Yulong Sun
Songming Chen
Jiaqi Zhou
Tao Han
Jiteng Wang
Sheenan Harpaz 

An integrated analysis of transcriptome and metabolome reveals three BCAAs relieve lipid accumulation by inhibiting lipid synthesis and promoting lipid oxidation in the liver of largemouth bass (Micropterus salmoides)

The intricate and paradoxical relationship between branched-chain amino acids (BCAAs) and lipid metabolism has been focused on the field of nutrition. However, the molecular mechanism mediated by BCAAs in the lipid metabolism of fish is poorly understood. To address this knowledge gap, we characterized the transcriptome and metabolome in the liver of largemouth bass (Micropterus salmoides), an extensively cultivated fish with high commercial value. Dietary BCAA supplementation significantly enhanced growth performance, combined with the elevation of essential amino acid levels and the improvement of liver health. Moreover, enzymatic detection and RT–qPCR results showed that BCAAs decreased lipid deposition in the liver. Integrated transcriptomics and metabolomics analysis revealed that the inhibition of lipid synthesis and enhancement of fatty acid degradation may explain the mechanism by which BCAAs relieved lipid accumulation in the liver. The metabolic enzymes acacaacaa2cpt2acat, and aldh9a1, which were regulated by all three BCAAs, are key targets linking BCAA metabolism and lipid metabolism. Considering that farmed fish suffer from abnormal lipid accumulation in the liver, appropriate BCAA supplementation is an effective nutritional strategy to improve lipid metabolism disorders in aquaculture.

Scientific Publication
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