נגישות
menu      
חיפוש מתקדם
תחביר
חפש...
הספר "אוצר וולקני"
אודות
תנאי שימוש
ניהול
קהילה:
אסיף מאגר המחקר החקלאי
פותח על ידי קלירמאש פתרונות בע"מ -
A liquid chromatographic method for the determination of atenolol in human plasma
Year:
1991
Source of publication :
Journal of Liquid Chromatography
Authors :
בן-דום, נעמי
;
.
Volume :
14
Co-Authors:
Teitelbaum, Z., Israel Institute for Biological Research, P.O. Box 19, Ness-Ziona, 70450, Israel
Ben-Dom, N., Israel Institute for Biological Research, P.O. Box 19, Ness-Ziona, 70450, Israel
Terry, S., Israel Institute for Biological Research, P.O. Box 19, Ness-Ziona, 70450, Israel
Facilitators :
From page:
3735
To page:
3744
(
Total pages:
10
)
Abstract:
A reliable, highly reproducible, accurate and time-efficient high performance liquid chromatographic (HPLC) method to measure atenolol concentration in human plasma was developed and validated. Sample clean-up consists of simple and efficient liquid-liquid extraction (mean recovery 103%) which allows a high sample throughput. Chromatography on a CN-propyl column yields symmetrical and well resolved peaks for atenolol and for the internal standard (metoprolol) without any interference from endogenous plasma components. Using 1 ml plasma samples the method has a limit of detection of 12.6 ng/ml (calculated at a 99.9% confidence level) with %CV (precision) s 8.8% and bias (accuracy) s 3.8% for concentrations in the range of 10 - 1000 ng/ml. We now routinely use this method in human pharmacokinetic studies of atenolol dosage forms. Copyright © 1991 by Marcel Dekker, Inc.
Note:
Related Files :
Atenolol
Chromatographic Analysis - High Performance Liquid
diet restriction
Drug products
oral drug administration
עוד תגיות
תוכן קשור
More details
DOI :
10.1080/01483919108049490
Article number:
Affiliations:
Database:
סקופוס
Publication Type:
מאמר
;
.
Language:
אנגלית
Editors' remarks:
ID:
22918
Last updated date:
02/03/2022 17:27
Creation date:
16/04/2018 23:55
Scientific Publication
A liquid chromatographic method for the determination of atenolol in human plasma
14
Teitelbaum, Z., Israel Institute for Biological Research, P.O. Box 19, Ness-Ziona, 70450, Israel
Ben-Dom, N., Israel Institute for Biological Research, P.O. Box 19, Ness-Ziona, 70450, Israel
Terry, S., Israel Institute for Biological Research, P.O. Box 19, Ness-Ziona, 70450, Israel
A liquid chromatographic method for the determination of atenolol in human plasma
A reliable, highly reproducible, accurate and time-efficient high performance liquid chromatographic (HPLC) method to measure atenolol concentration in human plasma was developed and validated. Sample clean-up consists of simple and efficient liquid-liquid extraction (mean recovery 103%) which allows a high sample throughput. Chromatography on a CN-propyl column yields symmetrical and well resolved peaks for atenolol and for the internal standard (metoprolol) without any interference from endogenous plasma components. Using 1 ml plasma samples the method has a limit of detection of 12.6 ng/ml (calculated at a 99.9% confidence level) with %CV (precision) s 8.8% and bias (accuracy) s 3.8% for concentrations in the range of 10 - 1000 ng/ml. We now routinely use this method in human pharmacokinetic studies of atenolol dosage forms. Copyright © 1991 by Marcel Dekker, Inc.
Scientific Publication
You may also be interested in