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פותח על ידי קלירמאש פתרונות בע"מ -
Effect of a chitin derivative in combination with cleaning and preservation solutions for contact lenses on adherence of fungi
Year:
2003
Source of publication :
Mycoses
Authors :
סיונוב, אדוארד
;
.
Volume :
46
Co-Authors:
Rotman, S., Department of Ophthalmology, Assaf Harofe Medical Center, Zrifin, Israel
Sandovsky-Losica, H., Department of Human Microbiology, Sackler School of Medicine, Tel-Aviv University, Tel-Aviv, Israel
Sionov, E., Department of Human Microbiology, Sackler School of Medicine, Tel-Aviv University, Tel-Aviv, Israel
Segal, E., Department of Human Microbiology, Sackler School of Medicine, Tel-Aviv University, Tel-Aviv, Israel, Department of Human Microbiology, Sackler School of Medicine, Tel-Aviv University, Tel-Aviv 69697, Israel
Facilitators :
From page:
90
To page:
95
(
Total pages:
6
)
Abstract:
The objective of the study was to evaluate the effect of supplementation of a chitin soluble extract (CSE) to clinically used commercial contact lenses' cleaning/preservation solutions on adherence of Aspergillus niger and Candida albicans to contact lenses. CSE (25 mg ml-1) was added to Solocare® or Oxysept®. Adherence of A. niger or C. albicans to contact lenses was assessed by exposing lenses to fungi in test solutions and enumeration of fungal colony forming unit. The study included three parts: (i) the disinfecting and adherence-inhibiting effect of Solocare and Oxysept; (ii) the adherence-inhibiting effect of CSE: (iii) the effect of Solocare + CSE or Oxysept + CSE on the fungal adherence to contact lenses. The experiments showed that: (i) Solocare had a significant disinfecting effect on A. niger and C. albicans while that of Oxysept was only minimal. (ii) Neither Solocare nor Oxysept had an inhibitory effect on the fungal adherence. (iii) CSE inhibited significantly the adherence of A. niger and C. albicans. (iv) Addition of CSE to Solocare or Oxysept resulted in almost complete inhibition of adherence. Supplementing CSE to lenses' maintenance solutions increases their antifungal potential by adding anti-adherence activity to the disinfecting effect of these solutions, bearing the potential to serve as a prophylactic means.
Note:
Related Files :
adhesion
antifungal activity
Cell Adhesion
chitin derivative
Fungal adherence
fungi
oxysept
Solocare
עוד תגיות
תוכן קשור
More details
DOI :
10.1046/j.1439-0507.2003.00858.x
Article number:
Affiliations:
Database:
סקופוס
Publication Type:
מאמר
;
.
Language:
אנגלית
Editors' remarks:
ID:
23679
Last updated date:
02/03/2022 17:27
Creation date:
17/04/2018 00:01
Scientific Publication
Effect of a chitin derivative in combination with cleaning and preservation solutions for contact lenses on adherence of fungi
46
Rotman, S., Department of Ophthalmology, Assaf Harofe Medical Center, Zrifin, Israel
Sandovsky-Losica, H., Department of Human Microbiology, Sackler School of Medicine, Tel-Aviv University, Tel-Aviv, Israel
Sionov, E., Department of Human Microbiology, Sackler School of Medicine, Tel-Aviv University, Tel-Aviv, Israel
Segal, E., Department of Human Microbiology, Sackler School of Medicine, Tel-Aviv University, Tel-Aviv, Israel, Department of Human Microbiology, Sackler School of Medicine, Tel-Aviv University, Tel-Aviv 69697, Israel
Effect of a chitin derivative in combination with cleaning and preservation solutions for contact lenses on adherence of fungi
The objective of the study was to evaluate the effect of supplementation of a chitin soluble extract (CSE) to clinically used commercial contact lenses' cleaning/preservation solutions on adherence of Aspergillus niger and Candida albicans to contact lenses. CSE (25 mg ml-1) was added to Solocare® or Oxysept®. Adherence of A. niger or C. albicans to contact lenses was assessed by exposing lenses to fungi in test solutions and enumeration of fungal colony forming unit. The study included three parts: (i) the disinfecting and adherence-inhibiting effect of Solocare and Oxysept; (ii) the adherence-inhibiting effect of CSE: (iii) the effect of Solocare + CSE or Oxysept + CSE on the fungal adherence to contact lenses. The experiments showed that: (i) Solocare had a significant disinfecting effect on A. niger and C. albicans while that of Oxysept was only minimal. (ii) Neither Solocare nor Oxysept had an inhibitory effect on the fungal adherence. (iii) CSE inhibited significantly the adherence of A. niger and C. albicans. (iv) Addition of CSE to Solocare or Oxysept resulted in almost complete inhibition of adherence. Supplementing CSE to lenses' maintenance solutions increases their antifungal potential by adding anti-adherence activity to the disinfecting effect of these solutions, bearing the potential to serve as a prophylactic means.
Scientific Publication
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