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Immunolocalization of osteonectin in avian tibial dyschondroplastic cartilage
Year:
1996
Source of publication :
Developmental Dynamics
Authors :
Hurvitz, Shmuel (Animal science)
;
.
Pines, Mark
;
.
Volume :
207
Co-Authors:
Jianxin, W.U., Department of Poultry Science, Pennsylvania State University, University Park, PA 16802, United States
Pines, M., Institute of Animal Science, Agricultural Research Organization, Volcani Center, Bet Dagan 50250, Israel
Gay, C.V., Department of Poultry Science, Pennsylvania State University, University Park, PA 16802, United States, Dept. of Biochem. and Molec. Biology, Pennsylvania State University, University Park, PA 16802, United States
Hurwitz, S., Institute of Animal Science, Agricultural Research Organization, Volcani Center, Bet Dagan 50250, Israel
Leach Jr., R.M., Department of Poultry Science, Pennsylvania State University, University Park, PA 16802, United States, Department of Poultry Science, 213 Wm. L. Henning Building, University Park, PA 16802-3501, United States
Facilitators :
From page:
69
To page:
74
(
Total pages:
6
)
Abstract:
Osteonectin is an acidic calcium-binding protein found in cartilage, bone matrix, vascular endothelium, and areas of tissue repair. Using immunocytochemistry, osteonectin has been localized in all zones of the normal avian epiphyseal growth plate with notably high amounts in the hypertrophic zone. In the proximal portion of this zone the staining was intracellular, while in the distal calcifying portion of the hypertrophic zone staining was both intracellular and extracellular. Osteonectin was also detected in the growth plate associated with lesions of chickens with tibial dyschondroplasia (TD). Intense intracellular staining was observed in hypertrophic chondrocytes proximal to the lesion; staining was markedly diminished in the TD lesion; extracellular matrix was devoid of staining. Staining intensity was high along the peripheral edges of the lesion that were undergoing vascularization and resorption. This was the only area in the dysplastic cartilage where staining was observed in the extracellular matrix as well as intracellularly. Similar patterns were viewed in all TD lesions examined, whether they were spontaneous or induced by dietary treatments or genetic selection.
Note:
Related Files :
Animals
animal tissue
Chickens
Growth plate
Male
Osteochondrodysplasias
Show More
Related Content
More details
DOI :
10.1002/(SICI)1097-0177(199609)207:1<69::AID-AJA7>3.3.CO;2-G
Article number:
0
Affiliations:
Database:
Scopus
Publication Type:
article
;
.
Language:
English
Editors' remarks:
ID:
18866
Last updated date:
21/08/2022 07:45
Creation date:
16/04/2018 23:24
Scientific Publication
Immunolocalization of osteonectin in avian tibial dyschondroplastic cartilage
207
Jianxin, W.U., Department of Poultry Science, Pennsylvania State University, University Park, PA 16802, United States
Pines, M., Institute of Animal Science, Agricultural Research Organization, Volcani Center, Bet Dagan 50250, Israel
Gay, C.V., Department of Poultry Science, Pennsylvania State University, University Park, PA 16802, United States, Dept. of Biochem. and Molec. Biology, Pennsylvania State University, University Park, PA 16802, United States
Hurwitz, S., Institute of Animal Science, Agricultural Research Organization, Volcani Center, Bet Dagan 50250, Israel
Leach Jr., R.M., Department of Poultry Science, Pennsylvania State University, University Park, PA 16802, United States, Department of Poultry Science, 213 Wm. L. Henning Building, University Park, PA 16802-3501, United States
Immunolocalization of osteonectin in avian tibial dyschondroplastic cartilage
Osteonectin is an acidic calcium-binding protein found in cartilage, bone matrix, vascular endothelium, and areas of tissue repair. Using immunocytochemistry, osteonectin has been localized in all zones of the normal avian epiphyseal growth plate with notably high amounts in the hypertrophic zone. In the proximal portion of this zone the staining was intracellular, while in the distal calcifying portion of the hypertrophic zone staining was both intracellular and extracellular. Osteonectin was also detected in the growth plate associated with lesions of chickens with tibial dyschondroplasia (TD). Intense intracellular staining was observed in hypertrophic chondrocytes proximal to the lesion; staining was markedly diminished in the TD lesion; extracellular matrix was devoid of staining. Staining intensity was high along the peripheral edges of the lesion that were undergoing vascularization and resorption. This was the only area in the dysplastic cartilage where staining was observed in the extracellular matrix as well as intracellularly. Similar patterns were viewed in all TD lesions examined, whether they were spontaneous or induced by dietary treatments or genetic selection.
Scientific Publication
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