Purpose: Mutations in the CNGA3 gene cause achromatopsia in humans. We identified a spontaneously-arising sheep model for this disease (Shamir et. al., Vet J. 185(2):130-7, 2010; Reicher et al., Genomics 95:101-4, 2010), and used this model to test the efficacy and safety of viral vector-mediated gene therapy.
Purpose: Mutations in the CNGA3 gene cause achromatopsia in humans. We identified a spontaneously-arising sheep model for this disease (Shamir et. al., Vet J. 185(2):130-7, 2010; Reicher et al., Genomics 95:101-4, 2010), and used this model to test the efficacy and safety of viral vector-mediated gene therapy.