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פותח על ידי קלירמאש פתרונות בע"מ -
Functional expression of an alpha anti-insect scorpion neurotoxin in insect cells and lepidopterous larvae
Year:
1995
Source of publication :
FEBS Letters
Authors :
צ'חנובסקי, נור
;
.
ריבקין, הדסה
;
.
Volume :
376
Co-Authors:
Chejanovsky, N., Institute of Plant Protection, ARO, Volcani Center, Bet Dagan, 50250, Israel
Zilberberg, N., Department of Botany, Tel-Aviv University, Tel Aviv, 69978, Israel
Rivkin, H., Institute of Plant Protection, ARO, Volcani Center, Bet Dagan, 50250, Israel
Zlotkin, E., Institute of Life Sciences, The Hebrew University of Jerusalem, Jerusalem, 91904, Israel
Gurevitz, M., Department of Botany, Tel-Aviv University, Tel Aviv, 69978, Israel
Facilitators :
From page:
181
To page:
184
(
Total pages:
4
)
Abstract:
The Leiurus quinquestriatus hebraeus alpha anti-insect toxin (LqhαIT) cDNA was engineered into the Autographa californica Nuclear Polyhedrosis Virus (AcNPV) genome. Insect cells infected with the recombinant virus secreted a functional LqhαIT polypeptide. Spodoptera littoralis and Heliothis armigera larvae injected with recombinant budded virus, showed typical intoxication symptoms. This recombinant virus showed enhanced insecticidal potency against H. armigera larvae compared with wild type AcNPV. The present expression system will facilitate: (1) the future elucidation of structural elements involved in its prominent anti-insect toxicity; and (2) the future design of genetically modified alpha toxins with improved anti-insect selectivity. © 1995.
Note:
Related Files :
Animal
animal cell
Base Sequence
dna transfer
gene expression
Moths
Neurotoxin
עוד תגיות
תוכן קשור
More details
DOI :
10.1016/0014-5793(95)01263-4
Article number:
Affiliations:
Database:
סקופוס
Publication Type:
מאמר
;
.
Language:
אנגלית
Editors' remarks:
ID:
20889
Last updated date:
02/03/2022 17:27
Creation date:
16/04/2018 23:39
You may also be interested in
Scientific Publication
Functional expression of an alpha anti-insect scorpion neurotoxin in insect cells and lepidopterous larvae
376
Chejanovsky, N., Institute of Plant Protection, ARO, Volcani Center, Bet Dagan, 50250, Israel
Zilberberg, N., Department of Botany, Tel-Aviv University, Tel Aviv, 69978, Israel
Rivkin, H., Institute of Plant Protection, ARO, Volcani Center, Bet Dagan, 50250, Israel
Zlotkin, E., Institute of Life Sciences, The Hebrew University of Jerusalem, Jerusalem, 91904, Israel
Gurevitz, M., Department of Botany, Tel-Aviv University, Tel Aviv, 69978, Israel
Functional expression of an alpha anti-insect scorpion neurotoxin in insect cells and lepidopterous larvae
The Leiurus quinquestriatus hebraeus alpha anti-insect toxin (LqhαIT) cDNA was engineered into the Autographa californica Nuclear Polyhedrosis Virus (AcNPV) genome. Insect cells infected with the recombinant virus secreted a functional LqhαIT polypeptide. Spodoptera littoralis and Heliothis armigera larvae injected with recombinant budded virus, showed typical intoxication symptoms. This recombinant virus showed enhanced insecticidal potency against H. armigera larvae compared with wild type AcNPV. The present expression system will facilitate: (1) the future elucidation of structural elements involved in its prominent anti-insect toxicity; and (2) the future design of genetically modified alpha toxins with improved anti-insect selectivity. © 1995.
Scientific Publication
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