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Antioxidant activity and inhibition of α-glucosidase by trans-resveratrol, piceid, and a novel trans-stilbene from the roots of Israeli Rumex bucephalophorus L.
Year:
2006
Authors :
Flaishman, Moshe
;
.
Sivan, Lior
;
.
Volume :
54
Co-Authors:
Kerem, Z., Institute of Biochemistry, Food Science, and Nutrition, Faculty of Agricultural, Food, and Environmental Quality Sciences, Hebrew University of Jerusalem, P.O. Box 12, Rehovot 76100, Israel
Bilkis, I., Institute of Biochemistry, Food Science, and Nutrition, Faculty of Agricultural, Food, and Environmental Quality Sciences, Hebrew University of Jerusalem, P.O. Box 12, Rehovot 76100, Israel
Flaishman, M.A., Department of Fruit Trees, Institute of Horticulture, Volcani Center, P.O. Box 6, Bet Dagan 50250, Israel
Sivan, L., Institute of Biochemistry, Food Science, and Nutrition, Faculty of Agricultural, Food, and Environmental Quality Sciences, Hebrew University of Jerusalem, P.O. Box 12, Rehovot 76100, Israel, Department of Fruit Trees, Institute of Horticulture, Volcani Center, P.O. Box 6, Bet Dagan 50250, Israel
Facilitators :
From page:
1243
To page:
1247
(
Total pages:
5
)
Abstract:
The roots of Rumex bucephalophorus, collected in Israel, were analyzed for trans-stilbenes. Two stilbene-O-glycosyl derivatives were identified, in addition to 3,5,4′-trihydroxystilbene (1) (resveratrol). The stilbene-O-glycosyl derivatives were 5,4′-dihydroxystilbene-3-O-β-D- glucopyranoside (2) (piceid) and the new 5,4′-dihydroxystilbene-3-O- α-arabinopyranoside (3), which is being named rumexoid. The structure of rumexoid was elucidated by using spectroscopic data. The antioxidant capacities of stilbenoids 1-3 were determined and expressed as trolox equivalent antioxidant capacity (TEAC). TEAC value for trans-resveratrol was highest (2.7) and for rumexoid lowest (1.5). In vitro, trans-resveratrol and rumexoid demonstrated a potent inhibitory effect on α-glucosidase activity (IC50 < 0.1 and < 0.5 mM, respectively). The commercial antidiabetic agent acarbose was shown to inhibit only 35% of the enzyme activity at 0.5 mM. The addition of piceid to the reaction mixture did not inhibit α-glucosidase in vitro in the range of concentrations used. These findings extend the range of reported beneficial effects of stilbene derivatives, and demonstrate the multifaceted activities that dietary polyphenols may exert in the intestine, where their concentrations are highest in the body. © 2006 American Chemical Society.
Note:
Related Files :
antioxidants
Chromatography, High Pressure Liquid
polydatin
Polygonaceae
Resveratrol
Show More
Related Content
More details
DOI :
10.1021/jf052436+
Article number:
Affiliations:
Database:
Scopus
Publication Type:
article
;
.
Language:
English
Editors' remarks:
ID:
22049
Last updated date:
02/03/2022 17:27
Creation date:
16/04/2018 23:49
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Scientific Publication
Antioxidant activity and inhibition of α-glucosidase by trans-resveratrol, piceid, and a novel trans-stilbene from the roots of Israeli Rumex bucephalophorus L.
54
Kerem, Z., Institute of Biochemistry, Food Science, and Nutrition, Faculty of Agricultural, Food, and Environmental Quality Sciences, Hebrew University of Jerusalem, P.O. Box 12, Rehovot 76100, Israel
Bilkis, I., Institute of Biochemistry, Food Science, and Nutrition, Faculty of Agricultural, Food, and Environmental Quality Sciences, Hebrew University of Jerusalem, P.O. Box 12, Rehovot 76100, Israel
Flaishman, M.A., Department of Fruit Trees, Institute of Horticulture, Volcani Center, P.O. Box 6, Bet Dagan 50250, Israel
Sivan, L., Institute of Biochemistry, Food Science, and Nutrition, Faculty of Agricultural, Food, and Environmental Quality Sciences, Hebrew University of Jerusalem, P.O. Box 12, Rehovot 76100, Israel, Department of Fruit Trees, Institute of Horticulture, Volcani Center, P.O. Box 6, Bet Dagan 50250, Israel
Antioxidant activity and inhibition of α-glucosidase by trans-resveratrol, piceid, and a novel trans-stilbene from the roots of Israeli Rumex bucephalophorus L.
The roots of Rumex bucephalophorus, collected in Israel, were analyzed for trans-stilbenes. Two stilbene-O-glycosyl derivatives were identified, in addition to 3,5,4′-trihydroxystilbene (1) (resveratrol). The stilbene-O-glycosyl derivatives were 5,4′-dihydroxystilbene-3-O-β-D- glucopyranoside (2) (piceid) and the new 5,4′-dihydroxystilbene-3-O- α-arabinopyranoside (3), which is being named rumexoid. The structure of rumexoid was elucidated by using spectroscopic data. The antioxidant capacities of stilbenoids 1-3 were determined and expressed as trolox equivalent antioxidant capacity (TEAC). TEAC value for trans-resveratrol was highest (2.7) and for rumexoid lowest (1.5). In vitro, trans-resveratrol and rumexoid demonstrated a potent inhibitory effect on α-glucosidase activity (IC50 < 0.1 and < 0.5 mM, respectively). The commercial antidiabetic agent acarbose was shown to inhibit only 35% of the enzyme activity at 0.5 mM. The addition of piceid to the reaction mixture did not inhibit α-glucosidase in vitro in the range of concentrations used. These findings extend the range of reported beneficial effects of stilbene derivatives, and demonstrate the multifaceted activities that dietary polyphenols may exert in the intestine, where their concentrations are highest in the body. © 2006 American Chemical Society.
Scientific Publication
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